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Molecular epidemiology of carbapenem‐resistant Acinetobacter baumannii isolated from three major hospitals in Jordan

Ababneh, Qutaiba ; Aldaken, Neda’a ; Jaradat, Ziad ; Al Sbei, Sara ; Alawneh, Dua’a ; Al‐zoubi, Esra’a ; Alhomsi, Tasnim ; Saadoun, Ismail

International journal of clinical practice (Esher), 2021-12, Vol.75 (12), p.e14998-n/a [Periódico revisado por pares]

England: Hindawi Limited

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  • Título:
    Molecular epidemiology of carbapenem‐resistant Acinetobacter baumannii isolated from three major hospitals in Jordan
  • Autor: Ababneh, Qutaiba ; Aldaken, Neda’a ; Jaradat, Ziad ; Al Sbei, Sara ; Alawneh, Dua’a ; Al‐zoubi, Esra’a ; Alhomsi, Tasnim ; Saadoun, Ismail
  • Assuntos: Acinetobacter baumannii ; Acinetobacter baumannii - genetics ; Acinetobacter Infections - drug therapy ; Acinetobacter Infections - epidemiology ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Antimicrobial agents ; Bacterial Proteins - genetics ; beta-Lactamases - genetics ; Carbapenems ; Carbapenems - pharmacology ; Epidemiology ; Hospitals ; Humans ; Jordan - epidemiology ; Microbial Sensitivity Tests ; Molecular Epidemiology ; Multidrug resistance ; Multilocus Sequence Typing ; Polymyxins ; Tigecycline
  • É parte de: International journal of clinical practice (Esher), 2021-12, Vol.75 (12), p.e14998-n/a
  • Notas: Funding information
    This study was funded by the deanship of research (grant no. 20170409) at Jordan University of Science and Technology.
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  • Descrição: Background In the last decade, incidences of carbapenem‐resistant Acinetobacter baumannii have been increasingly reported worldwide. Consequently, A. baumannii was included in the World Health Organization's new list of critical pathogens, for which new drugs are desperately needed. The objective of this research was to study the molecular epidemiology and antimicrobial susceptibility of clinical carbapenem‐resistant A. baumannii isolated from Jordanian hospitals. Methods A total of 78 A. baumannii and 8 Acinetobacter spp. isolates were collected from three major hospitals in Jordan during 2018. Disc diffusion and microdilution methods were used to test their susceptibility against 19 antimicrobial agents. Multilocus sequence typing (MLST) was performed using the Pasteur scheme, followed by eBURST analysis for all isolates. PCR was used to detect β‐lactam resistance genes, blaOXA‐23‐like, blaOXA‐51‐like, and blaNDM‐1. Results Of the 86 tested isolates, 78 (90.6%) exhibited resistance to carbapenems, whereas no resistance was recorded to tigecycline or polymyxins. Based on the resistance profiles, 10.4% and 84.8% of isolates were classified into multidrug resistant (MDR) or extensively drug resistant (XDR), respectively. The most prevalent carbapenems resistance genes amongst isolates were blaOXA‐51‐Like (89.5%), followed by blaOXA‐23‐Like (88.3%) and blaNDM‐1 (10.4%). MLST revealed the presence of 19 sequence types (STs), belonging to eight different international complexes. The most commonly detected clonal complex (CC) was CC2, representing 64% of all typed isolates. Conclusions This is the first study to report the clonal diversity of A. baumannii isolates in Jordan. A high incidence of carbapenem resistance was detected in the isolates investigated. In addition, our findings provided evidence for the widespread of blaOXA‐23‐like harbouring carbapenem‐resistant A. baumannii and belonging to CC2. The number of XDR isolates identified in this study is alarming. Thus, periodic surveillance and molecular epidemiological studies of resistance factors are important to improve treatment outcomes and prevent the spread of A. baumannii infections.
  • Editor: England: Hindawi Limited
  • Idioma: Inglês
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