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Alzheimer's disease: a tale of two diseases?

Nardini, Eleonora ; Hogan, Ryan ; Flamier, Anthony ; Bernier, Gilbert

Neural regeneration research, 2021-10, Vol.16 (10), p.1958-1964 [Periódico revisado por pares]

India: Wolters Kluwer India Pvt. Ltd

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  • Título:
    Alzheimer's disease: a tale of two diseases?
  • Autor: Nardini, Eleonora ; Hogan, Ryan ; Flamier, Anthony ; Bernier, Gilbert
  • Assuntos: aging; alzheimer’s disease; bmi1; epigenetics; familial; late-onset; sporadic ; Alzheimer's disease ; Amyloid beta-protein ; Care and treatment ; Development and progression ; Gene expression ; Gene mutations ; Genetic aspects ; Health aspects ; Presenilins ; Review ; Rodents
  • É parte de: Neural regeneration research, 2021-10, Vol.16 (10), p.1958-1964
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    These authors contributed equally to this work.
    Author contributions: Conceptualization: GB; writing—original draft preparation: RH; writing—review and editing: GB, AF, EN, and RH; visualization: AF and GB. All authors have read and agreed to the published version of the manuscript.
  • Descrição: Sporadic late-onset Alzheimer's disease (SLOAD) and familial early-onset Alzheimer's disease (FEOAD) associated with dominant mutations in APP, PSEN1 and PSEN2, are thought to represent a spectrum of the same disorder based on near identical behavioral and histopathological features. Hence, FEOAD transgenic mouse models have been used in past decades as a surrogate to study SLOAD pathogenic mechanisms and as the gold standard to validate drugs used in clinical trials. Unfortunately, such research has yielded little output in terms of therapeutics targeting the disease's development and progression. In this short review, we interrogate the widely accepted view of one, dimorphic disease through the prism of the Bmi1+/- mouse model and the distinct chromatin signatures observed between SLOAD and FEOAD brains.
  • Editor: India: Wolters Kluwer India Pvt. Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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