skip to main content
Idioma:

Longitudinal Modeling of Age-Related Memory Decline and the APOE ε4 Effect

Caselli, Richard J ; Dueck, Amylou C ; Osborne, David ; Sabbagh, Marwan N ; Connor, Donald J ; Ahern, Geoffrey L ; Baxter, Leslie C ; Rapcsak, Steven Z ; Shi, Jiong ; Woodruff, Bryan K ; Locke, Dona E.C ; Snyder, Charlene Hoffman ; Alexander, Gene E ; Rademakers, Rosa ; Reiman, Eric M

The New England journal of medicine, 2009-07, Vol.361 (3), p.255-263 [Periódico revisado por pares]

Waltham, MA: Massachusetts Medical Society

Texto completo disponível

Citações Citado por
  • Título:
    Longitudinal Modeling of Age-Related Memory Decline and the APOE ε4 Effect
  • Autor: Caselli, Richard J ; Dueck, Amylou C ; Osborne, David ; Sabbagh, Marwan N ; Connor, Donald J ; Ahern, Geoffrey L ; Baxter, Leslie C ; Rapcsak, Steven Z ; Shi, Jiong ; Woodruff, Bryan K ; Locke, Dona E.C ; Snyder, Charlene Hoffman ; Alexander, Gene E ; Rademakers, Rosa ; Reiman, Eric M
  • Assuntos: Biological and medical sciences ; General aspects ; Medical sciences
  • É parte de: The New England journal of medicine, 2009-07, Vol.361 (3), p.255-263
  • Descrição: The APOE ε4 variant confers an increased risk of Alzheimer's disease. Longitudinal modeling of cognitive aging showed that memory decline in subjects with one or two APOE ε4 alleles diverged from that of noncarriers before the age of 60 years. The APOE ε4 variant confers an increased risk of Alzheimer's disease. Longitudinal modeling of cognitive aging showed that memory decline in subjects with one or two APOE ε4 alleles diverged from that of noncarriers before the age of 60 years. Cognitive profiles of normal aging emphasize a decline in skills mediated by the frontal lobe, including learning efficiency, working memory, and psychomotor speed. 1 – 3 Although memory loss is the earliest cognitive change in Alzheimer's disease, 4 – 9 distinguishing early disease from normal aging can be difficult. 10 , 11 The apolipoprotein E ( APOE ) ε4 allele, the most prevalent known genetic risk factor for Alzheimer's disease, may account for up to half of all sporadic and familial late-onset cases of Alzheimer's disease. 12 , 13 Carriers of the APOE ε4 allele have more rapidly progressive memory loss and reduced learning efficiency in their 50s . . .
  • Editor: Waltham, MA: Massachusetts Medical Society
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.