Idioma:

A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model

Machado, Daniel Escorsim, M.Sc ; Berardo, Plínio Tostes, M.D., Ph.D ; Landgraf, Richardt Gama, Ph.D ; Fernandes, Patrícia Dias, Ph.D ; Palmero, Celia, M.Sc ; Alves, Leandro Miranda, Ph.D ; Abrao, Maurício Simões, M.D., Ph.D ; Nasciutti, Luiz Eurico, Ph.D

Fertility and sterility, 2010-05, Vol.93 (8), p.2674-2679 [Periódico revisado por pares]

New York, NY: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model
Autor: Machado, Daniel Escorsim, M.Sc ; Berardo, Plínio Tostes, M.D., Ph.D ; Landgraf, Richardt Gama, Ph.D ; Fernandes, Patrícia Dias, Ph.D ; Palmero, Celia, M.Sc ; Alves, Leandro Miranda, Ph.D ; Abrao, Maurício Simões, M.D., Ph.D ; Nasciutti, Luiz Eurico, Ph.D
Assuntos: Angiogenesis ; Angiogenesis Inhibitors - therapeutic use ; Animals ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; COX-2 inhibitor ; Cyclooxygenase 2 - biosynthesis ; Cyclooxygenase 2 Inhibitors - therapeutic use ; Disease Models, Animal ; endometriosis ; Endometriosis - drug therapy ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Internal Medicine ; Isoxazoles - therapeutic use ; Medical sciences ; Non tumoral diseases ; Obstetrics and Gynecology ; PGE 2 ; Pharmacology. Drug treatments ; Rats ; Rats, Sprague-Dawley ; Vascular Endothelial Growth Factor A - biosynthesis ; Vascular Endothelial Growth Factor Receptor-2 - biosynthesis ; vascularization ; VEGF
É parte de: Fertility and sterility, 2010-05, Vol.93 (8), p.2674-2679
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Objective To analyze the antiangiogenic effects of the selective cyclooxygenase-2 (COX-2) inhibitor parecoxib on the growth of endometrial implants in a rat model of peritoneal endometriosis. Design Pharmacologic interventions in an experimental model of peritoneal endometriosis. Setting Research laboratory in the Federal University of Rio de Janeiro. Animal(s) Twenty female Sprague-Dawley rats with experimentally induced endometriosis. Intervention(s) After implantation and establishment of autologous endometrium onto the peritoneum abdominal wall, rats were randomized into groups and treated with parecoxib or the vehicle by IM injection for 30 days. Main Outcome Measure(s) Vascular density, the expression of vascular endothelial growth factor (VEGF) and its receptor Flk-1, the distribution of activated macrophages, the expression of COX-2, and the prostaglandin concentration in the endometriotic lesions treated with parecoxib were analyzed. Result(s) The treatment significantly decreased the implant size, and histologic examination indicated mostly atrophy and regression. A reduction in microvessel density and in the number of macrophages, associated with decreased expression of VEGF and Flk-1, also were observed. The treatment group showed a low concentration of prostaglandin E2. Conclusion(s) These results suggest that the use of COX-2 selective inhibitors could be effective to suppress the establishment and growth of endometriosis, partially through their antiangiogenic activity.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model

Machado, Daniel Escorsim, M.Sc ; Berardo, Plínio Tostes, M.D., Ph.D ; Landgraf, Richardt Gama, Ph.D ; Fernandes, Patrícia Dias, Ph.D ; Palmero, Celia, M.Sc ; Alves, Leandro Miranda, Ph.D ; Abrao, Maurício Simões, M.D., Ph.D ; Nasciutti, Luiz Eurico, Ph.D

New York, NY: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.