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Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity

Mu, Chaojing ; Wu, Qingsheng

Nanoscale research letters, 2017-04, Vol.12 (1), p.318-8, Article 318 [Periódico revisado por pares]

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Título:
Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity
Autor: Mu, Chaojing ; Wu, Qingsheng
Assuntos: Anticancer properties ; Anticancer reagent ; Antitumor activity ; Chemistry and Materials Science ; Cis-diamminediiodoplatinum ; Cisplatin ; Controlled release ; Cross-resistance ; Drug carrier ; Electrospinning ; Electrospun nanofibers ; Materials Science ; Molecular Medicine ; Nano Express ; Nanochemistry ; Nanofibers ; Nanoscale Science and Technology ; Nanotechnology ; Nanotechnology and Microengineering ; Polycaprolactone ; Toxicity ; Tumor cells
É parte de: Nanoscale research letters, 2017-04, Vol.12 (1), p.318-8, Article 318
Descrição: Poly(ε-caprolactone) (PCL) nanofibers were prepared by electrospun, on which the cis -diamminediiodoplatinum ( cis- DIDP) was loaded, cis -DIDP@PCL, which effectively overcame cis- DIDP from dissociation or premature interaction with other bimolecular groups. Meanwhile, the toxicity and cross-resistance of cis -DIDP were reduced greatly. In vitro, cis- DIDP released from the PCL nanofibers eradicated the tumor cells around twice times more than free cis- DIDP, even better than cisplatin. Furthermore, cis -DIDP@PCL could controllably release cis- DIDP in different sustained-release solution based on our experiment.
Editor: New York: Springer US
Idioma: Inglês

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