skip to main content
Idioma:

Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure

Chen, Xiaoqing ; Xu, Sudan ; Zhao, Chunxia ; Liu, Bei

Biochemical and biophysical research communications, 2019-08, Vol.516 (1), p.37-43 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por
  • Título:
    Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure
  • Autor: Chen, Xiaoqing ; Xu, Sudan ; Zhao, Chunxia ; Liu, Bei
  • Assuntos: Autophagy ; Ferroptosis ; Heart failure ; NOX4 ; TLR4
  • É parte de: Biochemical and biophysical research communications, 2019-08, Vol.516 (1), p.37-43
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Loss of myocytes caused by cell death plays a key role during heart failure (HF). Activated autophagy and increased ferroptosis have been observed in HF and proved to promote its progression. However, the underlying mechanisms remain unclear. Here, results from integrated bioinformatical analysis showed TLR4 and NADPH oxidase 4 (NOX4) were included in up-regulated differentially expressed genes (DEGs), and had an interaction between each other inferred by the DEGs-associated protein-protein interaction (PPI) network. To explore the role of TLR4-NOX4 in autophagy and ferroptosis, knock-down of TLR4 and NOX4 through lentiviral delivery of siRNA to the myocardium were applied respectively in HF rats induced by aortic banding, and the indicators of autophagy and ferroptosis were detected. Results revealed that either TLR4 or NOX4 knock-down significantly improved left ventricular remodeling and reduced myocytes death. Simultaneously, activated autophagy and ferroptosis in rats with HF were remarkably retarded by either TLR4 and NOX4 knock-down, suggesting TLR4-NOX4 as a potential therapeutic target for HF through inhibiting autophagy- and ferroptosis-mediated cell death. •TLR4 and NOX4 were up-regulated accompanied by activated autophagy and increased ferroptosis during heart failure.•Either TLR4- or NOX4 knock-down significantly reduced myocyte death.•Either TLR4- or NOX4 knock-down significantly inhibited autophagy and ferroptosis.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
Links
Voltar para lista de resultados
Ir para página anteriorAnterior Resultado  13 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.