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A One-Pot Process for the Enantioselective Synthesis of Amines via Reductive Amination under Transfer Hydrogenation Conditions

Williams, Glynn D ; Pike, Richard A ; Wade, Charles E ; Wills, Martin

Organic letters, 2003-10, Vol.5 (22), p.4227-4230 [Periódico revisado por pares]

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Título:
A One-Pot Process for the Enantioselective Synthesis of Amines via Reductive Amination under Transfer Hydrogenation Conditions
Autor: Williams, Glynn D ; Pike, Richard A ; Wade, Charles E ; Wills, Martin
É parte de: Organic letters, 2003-10, Vol.5 (22), p.4227-4230
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Cyclic amines may be prepared via a sequence of deprotection followed by intramolecular reductive amination of t-Boc-protected amino ketones under asymmetric transfer hydrogenation conditions. In cases where the corresponding imine reaction proceeds with high enantioselectivity, this is reflected in the one-step process.
Editor: United States: American Chemical Society
Idioma: Inglês

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