Idioma:

LncRNA MAYA promotes iron overload and hepatocyte senescence through inhibition of YAP in non‐alcoholic fatty liver disease

Yuan, Ping ; Qi, Xiaoyu ; Song, Anping ; Ma, Mingyue ; Zhang, Xinbei ; Lu, Chunfeng ; Bian, Mianli ; Lian, Naqi ; He, Jianling ; Zheng, Shuguo ; Jin, Huanhuan

Journal of cellular and molecular medicine, 2021-08, Vol.25 (15), p.7354-7366 [Periódico revisado por pares]

England: John Wiley & Sons, Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
LncRNA MAYA promotes iron overload and hepatocyte senescence through inhibition of YAP in non‐alcoholic fatty liver disease
Autor: Yuan, Ping ; Qi, Xiaoyu ; Song, Anping ; Ma, Mingyue ; Zhang, Xinbei ; Lu, Chunfeng ; Bian, Mianli ; Lian, Naqi ; He, Jianling ; Zheng, Shuguo ; Jin, Huanhuan
Assuntos: Animals ; Cell cycle ; Cell Line ; Cellular Senescence ; Cricetinae ; DNA Damage ; Experiments ; Fatty liver ; Hepatocytes ; Hepatocytes - metabolism ; Hepatocytes - physiology ; Heterochromatin ; Humans ; Iron ; Iron - metabolism ; iron overload ; Laboratory animals ; Liver diseases ; MAYA ; Mesocricetus ; Metabolism ; Non-alcoholic Fatty Liver Disease - genetics ; Non-alcoholic Fatty Liver Disease - metabolism ; non‐alcoholic fatty liver disease ; Original ; Pathogenesis ; Polymerase chain reaction ; Reagents ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Senescence ; Signal transduction ; Telomerase ; YAP-Signaling Proteins - genetics ; YAP-Signaling Proteins - metabolism ; Yes-associated protein
É parte de: Journal of cellular and molecular medicine, 2021-08, Vol.25 (15), p.7354-7366
Notas: Ping Yuan and Xiaoyu Qi contributed equally to this work.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Although recent evidence has shown that hepatocyte senescence plays a crucial role in the pathogenesis and development of non‐alcoholic fatty liver disease (NAFLD), the mechanism is still not clear. The purpose of this study was to investigate the signal transduction pathways involved in the senescence of hepatocyte, in order to provide a potential strategy for blocking the process of NAFLD. The results confirmed that hepatocyte senescence occurred in HFD‐fed Golden hamsters and PA‐treated LO2 cells as manifested by increased levels of senescence marker SA‐β‐gal, p16 and p21, heterochromatin marker H3K9me3, DNA damage marker γ‐H2AX and decreased activity of telomerase. Further studies demonstrated that iron overload could promote the senescence of hepatocyte, whereas the overexpression of Yes‐associated protein (YAP) could blunt iron overload and alleviate the senescence of hepatocyte. Of importance, depression of lncRNA MAYA (MAYA) reduced iron overload and cellular senescence via promotion of YAP in PA‐treated hepatocytes. These effects were further supported by in vivo experiments. In conclusion, these data suggested that inhibition of MAYA could up‐regulate YAP, which might repress hepatocyte senescence through modulating iron overload. In addition, these findings provided a promising option for heading off the development of NAFLD by abrogating hepatocyte senescence.
Editor: England: John Wiley & Sons, Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 15 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

LncRNA MAYA promotes iron overload and hepatocyte senescence through inhibition of YAP in non‐alcoholic fatty liver disease

Yuan, Ping ; Qi, Xiaoyu ; Song, Anping ; Ma, Mingyue ; Zhang, Xinbei ; Lu, Chunfeng ; Bian, Mianli ; Lian, Naqi ; He, Jianling ; Zheng, Shuguo ; Jin, Huanhuan

England: John Wiley & Sons, Inc

Buscando em bases de dados remotas. Favor aguardar.