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Histological Analyses of Capsular Contracture and Associated Risk Factors: A Systematic Review

Larsen, Andreas ; Rasmussen, Louise E. ; Rasmussen, Leonia F. ; Weltz, Tim K. ; Hemmingsen, Mathilde N. ; Poulsen, Steen S. ; Jacobsen, Jens C. B. ; Vester-Glowinski, Peter ; Herly, Mikkel

Aesthetic plastic surgery, 2021-12, Vol.45 (6), p.2714-2728 [Periódico revisado por pares]

New York: Springer US

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Título:
Histological Analyses of Capsular Contracture and Associated Risk Factors: A Systematic Review
Autor: Larsen, Andreas ; Rasmussen, Louise E. ; Rasmussen, Leonia F. ; Weltz, Tim K. ; Hemmingsen, Mathilde N. ; Poulsen, Steen S. ; Jacobsen, Jens C. B. ; Vester-Glowinski, Peter ; Herly, Mikkel
Assuntos: Breast Implantation - adverse effects ; Breast implants ; Breast Implants - adverse effects ; Breast surgery ; Connective tissue ; Contracture - etiology ; Histology ; Humans ; Implant Capsular Contracture - epidemiology ; Implant Capsular Contracture - etiology ; Implant Capsular Contracture - surgery ; Medicine ; Medicine & Public Health ; Morphology ; Otorhinolaryngology ; Patients ; Plastic Surgery ; Review ; Risk factors ; Systematic review
É parte de: Aesthetic plastic surgery, 2021-12, Vol.45 (6), p.2714-2728
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ObjectType-Undefined-4
Descrição: Background Capsular contracture is a severe complication to breast surgery with implants. Previous studies suggest multiple risk factors are associated with capsular contracture, but the etiology is still unknown. We performed a literature review to investigate existing studies on histological analyses of breast implant capsules and how clinical risk factors impact the capsule morphology. Methods The literature search was conducted in PubMed. Studies that performed histological analyses of breast implant capsules were included. Animal studies or studies with a study population of less than five patients were excluded. Results Fifty-two studies were included. The histological analyses showed that the breast implant capsules were organized in multiple layers with an inner layer of synovial-like metaplasia which was reported to diminish in capsules with capsular contracture. The remaining layers of the capsule mostly consisted of collagen. The alignment of the collagen fibers differed between contracted and non-contracted capsules, and capsules with higher Baker grade were generally thickest and contained more tissue inflammation. Studies investigating capsules affected by radiotherapy found a more pronounced inflammatory response and the capsules were generally thicker and fibrotic compared with nonirradiated capsules. Conclusions The included studies offer valuable insights into the histological changes caused by capsular contracture and their relation to clinical risk factors. Further studies with larger sample sizes and more strict inclusion criteria are needed to further investigate implant capsules and the role of the synovial-like metaplasia for the development of capsular contracture. Level of Evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors https://www.springer.com/00266 .
Editor: New York: Springer US
Idioma: Inglês

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Histological Analyses of Capsular Contracture and Associated Risk Factors: A Systematic Review

Larsen, Andreas ; Rasmussen, Louise E. ; Rasmussen, Leonia F. ; Weltz, Tim K. ; Hemmingsen, Mathilde N. ; Poulsen, Steen S. ; Jacobsen, Jens C. B. ; Vester-Glowinski, Peter ; Herly, Mikkel

New York: Springer US

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