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Citrobacter freundii impairs the phosphoryl transfer network in the gills of Rhamdia quelen: Impairment of bioenergetics homeostasis

Baldissera, Matheus D. ; Souza, Carine F. ; Junior, Guerino B. ; Moreira, Karen Luise S. ; da Veiga, Marcelo L. ; da Rocha, Maria Izabel U.M. ; Baldisserotto, Bernardo

Microbial pathogenesis, 2018-04, Vol.117, p.157-161 [Periódico revisado por pares]

England: Elsevier Ltd

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  • Título:
    Citrobacter freundii impairs the phosphoryl transfer network in the gills of Rhamdia quelen: Impairment of bioenergetics homeostasis
  • Autor: Baldissera, Matheus D. ; Souza, Carine F. ; Junior, Guerino B. ; Moreira, Karen Luise S. ; da Veiga, Marcelo L. ; da Rocha, Maria Izabel U.M. ; Baldisserotto, Bernardo
  • Assuntos: Adenylate kinase ; Aquaculture disease ; Creatine kinase ; Disease pathogenesis
  • É parte de: Microbial pathogenesis, 2018-04, Vol.117, p.157-161
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: The precise coupling of spatially separated intracellular adenosine triphosphate (ATP)-producing and ATP-consuming, catalyzed by creatine kinase (CK), adenylate kinase (AK), and pyruvate kinase (PK), is a critical process in the bioenergetics of tissues with high energy demand, such as the branchial tissue. The effects of Citrobacter freundii infection on gills remain poorly understood, limited only to histopathological studies. Thus, the aim of this study was to evaluate whether experimental infection by C. freundii impairs the enzymes of the phosphoryl transfer network in gills of silver catfish (Rhamdia quelen). The CK (cytosolic and mitochondrial) and AK activities decreased in infected compared to uninfected animals, while the PK activity did not differ between groups. The gill histopathology of infected animals revealed extensive degeneration with fusion and necrosis of secondary lamellae, detachment of superficial epithelium, aneurysm, vessel congestion and inflammatory process. Based on these evidences, the inhibition and absence of an efficient communication between CK compartments caused the impairment of the branchial bioenergetics homeostasis, which was not compensated by the augmentation on branchial AK activity in an attempt to restore energy homeostasis. In summary, these alterations contribute to disease pathogenesis linked to branchial tissue in animals infected with C. freundii. •Citrobacter freundii impairs branchial creatine kinase activity.•C. freundii inhibits branchial adenylate kinase and pyruvate kinase activities.•These alterations are linked to disease pathogenesis of C. freundii infection.
  • Editor: England: Elsevier Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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