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Outcomes of pediatric low-grade gliomas treated with radiation therapy: a single-institution study

Raikar, Sunil S ; Halloran, Donna R ; Elliot, Michael ; McHugh, Michele ; Patel, Shaun ; Gauvain, Karen M

Journal of pediatric hematology/oncology, 2014-08, Vol.36 (6), p.e366-e370 [Periódico revisado por pares]

United States

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Título:
Outcomes of pediatric low-grade gliomas treated with radiation therapy: a single-institution study
Autor: Raikar, Sunil S ; Halloran, Donna R ; Elliot, Michael ; McHugh, Michele ; Patel, Shaun ; Gauvain, Karen M
Assuntos: Adolescent ; Brain Neoplasms - pathology ; Brain Neoplasms - radiotherapy ; Brain Neoplasms - surgery ; Brain Stem Neoplasms - pathology ; Brain Stem Neoplasms - radiotherapy ; Brain Stem Neoplasms - surgery ; Child ; Child, Preschool ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Follow-Up Studies ; Glioma - pathology ; Glioma - radiotherapy ; Glioma - surgery ; Humans ; Hypothalamic Neoplasms - pathology ; Hypothalamic Neoplasms - radiotherapy ; Hypothalamic Neoplasms - surgery ; Male ; Neoplasm Grading ; Neoplasm Recurrence, Local - pathology ; Retrospective Studies ; Treatment Outcome ; Visual Pathways - pathology ; Young Adult
É parte de: Journal of pediatric hematology/oncology, 2014-08, Vol.36 (6), p.e366-e370
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Radiation therapy is often considered the treatment of choice for low-grade gliomas. However, given the long-term effects of radiation on the developing brain, the appropriate use of radiation therapy in pediatric patients remains controversial. The purpose of this study was to evaluate progression-free survival (PFS) of pediatric low-grade glioma patients treated with radiation therapy. Data were obtained through a retrospective chart review of patients treated between 1991 and 2008 from a single tertiary care center in the midwest. The study population consisted of 17 patients, of whom 8 (47%) had tumor recurrence after radiation therapy. The median follow-up time was 8.2 years, with a range of 2.3 to 17.2 years. The median age at diagnosis was 5.4 years, and the median age at radiation therapy was 9.4 years. The 3- and the 10-year PFS were 69%± 11.7% and 46%± 13.3%, respectively. A significant difference in PFS was seen when comparing brainstem tumors with hypothalamic/optic pathway tumors (P=0.019). Differences in PFS based on the age at diagnosis, the extent of initial surgery, and indication for radiation therapy were not significant. A larger multicenter study is needed to better assess PFS in these patients.
Editor: United States
Idioma: Inglês

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Outcomes of pediatric low-grade gliomas treated with radiation therapy: a single-institution study

Raikar, Sunil S ; Halloran, Donna R ; Elliot, Michael ; McHugh, Michele ; Patel, Shaun ; Gauvain, Karen M

United States

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