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Therapeutic failure in American cutaneous leishmaniasis is associated with gelatinase activity and cytokine expression

Maretti-Mira, A.C ; de Oliveira-Neto, M.P ; Da-Cruz, A.M ; de Oliveira, M.P ; Craft, N ; Pirmez, C

Clinical and experimental immunology, 2011-02, Vol.163 (2), p.207-214 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Therapeutic failure in American cutaneous leishmaniasis is associated with gelatinase activity and cytokine expression
Autor: Maretti-Mira, A.C ; de Oliveira-Neto, M.P ; Da-Cruz, A.M ; de Oliveira, M.P ; Craft, N ; Pirmez, C
Assuntos: Adult ; American tegumentary leishmaniasis ; Analytical, structural and metabolic biochemistry ; Antimony - therapeutic use ; Antiprotozoal Agents - therapeutic use ; Biological and medical sciences ; cytokines ; Cytokines - immunology ; Female ; Fundamental and applied biological sciences. Psychology ; Human protozoal diseases ; Humans ; Infectious diseases ; Interferon-gamma - immunology ; Interleukin-10 - immunology ; leishmaniasis immunology ; Leishmaniasis, Cutaneous - drug therapy ; Leishmaniasis, Cutaneous - enzymology ; Leishmaniasis, Cutaneous - immunology ; Leshmaniasis ; Male ; Matrix Metalloproteinase 2 - metabolism ; Matrix Metalloproteinase 9 - metabolism ; matrix metalloproteinases ; Medical sciences ; Meglumine - therapeutic use ; Organometallic Compounds - therapeutic use ; Parasitic diseases ; Protozoal diseases ; Regeneration ; Skin - enzymology ; Skin - pathology ; therapeutic failure ; Transforming Growth Factor beta - immunology ; Translational Studies ; Treatment Failure
É parte de: Clinical and experimental immunology, 2011-02, Vol.163 (2), p.207-214
Notas: http://dx.doi.org/10.1111/j.1365-2249.2010.04285.x
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SourceType-Scholarly Journals-1
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Descrição: Cutaneous lesions caused by Leishmania braziliensis infection occasionally heal spontaneously, but with antimonials therapy heal rapidly in approximately 3 weeks. However, about 15% of the cases require several courses of therapy. Matrix metalloproteinase-2 (MMP-2) and MMP-9 are gelatinases that have been implicated in other chronic cutaneous diseases and skin re-epithelialization. These enzymes are controlled by their natural inhibitors [tissue inhibitors of metalloproteinase (TIMPs)] and by some cytokines. Uncontrolled gelatinase activity may result in intense tissue degradation and, consequently, poorly healing wounds. The present study correlates gelatinase activity to therapeutic failure of cutaneous leishmaniasis (CL) lesions. Our results demonstrate an association between gelatinase activity and increased numbers of cells making interferon (IFN)-γ, interleukin (IL)-10 and transforming growth factor (TGF)-β in lesions from poor responders. Conversely, high levels of MMP-2 mRNA and enhanced MMP-2 : TIMP-2 ratios were associated with a satisfactory response to antimonials treatment. Additionally, high gelatinolytic activity was found in the wound beds, necrotic areas in the dermis and within some granulomatous infiltrates. These results indicate the importance of gelatinase activity in the skin lesions caused by CL. Thus, we hypothesize that the immune response profile may be responsible for the gelatinase activity pattern and may ultimately influence the persistence or cure of CL lesions.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Therapeutic failure in American cutaneous leishmaniasis is associated with gelatinase activity and cytokine expression

Maretti-Mira, A.C ; de Oliveira-Neto, M.P ; Da-Cruz, A.M ; de Oliveira, M.P ; Craft, N ; Pirmez, C

Oxford, UK: Blackwell Publishing Ltd

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