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Propagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body

Sitaraman, Divya ; Aso, Yoshinori ; Jin, Xin ; Chen, Nan ; Felix, Mario ; Rubin, Gerald M. ; Nitabach, Michael N.

Current biology, 2015-11, Vol.25 (22), p.2915-2927 [Periódico revisado por pares]

England: Elsevier Ltd

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  • Título:
    Propagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body
  • Autor: Sitaraman, Divya ; Aso, Yoshinori ; Jin, Xin ; Chen, Nan ; Felix, Mario ; Rubin, Gerald M. ; Nitabach, Michael N.
  • Assuntos: Animals ; Drosophila melanogaster - physiology ; Female ; Homeostasis - physiology ; Male ; Memory - physiology ; Mushroom Bodies - physiology ; Neurons - physiology ; Reproduction - physiology ; Sleep - physiology ; Smell - physiology ; Structure-Activity Relationship
  • É parte de: Current biology, 2015-11, Vol.25 (22), p.2915-2927
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Current address: Department of Psychological Sciences, University of San Diego, 5998 Alacala Park, San Diego, California 92110, USA.
  • Descrição: The Drosophila mushroom body (MB) is a key associative memory center that has also been implicated in the control of sleep. However, the identity of MB neurons underlying homeostatic sleep regulation, as well as the types of sleep signals generated by specific classes of MB neurons, has remained poorly understood. We recently identified two MB output neuron (MBON) classes whose axons convey sleep control signals from the MB to converge in the same downstream target region: a cholinergic sleep-promoting MBON class and a glutamatergic wake-promoting MBON class. Here, we deploy a combination of neurogenetic, behavioral, and physiological approaches to identify and mechanistically dissect sleep-controlling circuits of the MB. Our studies reveal the existence of two segregated excitatory synaptic microcircuits that propagate homeostatic sleep information from different populations of intrinsic MB “Kenyon cells” (KCs) to specific sleep-regulating MBONs: sleep-promoting KCs increase sleep by preferentially activating the cholinergic MBONs, while wake-promoting KCs decrease sleep by preferentially activating the glutamatergic MBONs. Importantly, activity of the sleep-promoting MB microcircuit is increased by sleep deprivation and is necessary for homeostatic rebound sleep (i.e., the increased sleep that occurs after, and in compensation for, sleep lost during deprivation). These studies reveal for the first time specific functional connections between subsets of KCs and particular MBONs and establish the identity of synaptic microcircuits underlying transmission of homeostatic sleep signals in the MB. •The fly mushroom body controls sleep through segregated synaptic microcircuits•Sleep deprivation activates a sleep-promoting microcircuit•This sleep-promoting microcircuit drives rebound recovery sleep after deprivation Sleep is an essential biological function found in almost all animals. However, the neural circuits that control sleep remain poorly understood. Sitaraman et al. used Drosophila flies as a model system to identify parallel segregated sleep-promoting and sleep-suppressing brain circuits that control the rebound recovery sleep that occurs after sleep deprivation.
  • Editor: England: Elsevier Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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