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Increased Intestinal Permeability Is Associated With Later Development of Crohn’s Disease

Turpin, Williams ; Lee, Sun-Ho ; Raygoza Garay, Juan Antonio ; Madsen, Karen L. ; Meddings, Jonathan B. ; Bedrani, Larbi ; Power, Namita ; Espin-Garcia, Osvaldo ; Xu, Wei ; Smith, Michelle I. ; Griffiths, Anne M. ; Moayyedi, Paul ; Turner, Dan ; Seidman, Ernest G. ; Steinhart, A. Hillary ; Marshall, John K. ; Jacobson, Kevan ; Mack, David ; Huynh, Hien ; Bernstein, Charles N. ; Paterson, Andrew D. ; Abreu, Maria ; Beck, Paul ; Bernstein, Charles ; Croitoru, Kenneth ; Dieleman, Leo ; Feagan, Brian ; Griffiths, Anne ; Guttman, David ; Jacobson, Kevan ; Kaplan, Gilaad ; Krause, Denis O. ; Madsen, Karen ; Marshall, John ; Moayyedi, Paul ; Ropeleski, Mark ; Seidman, Ernest ; Silverberg, Mark ; Snapper, Scott ; Stadnyk, Andy ; Steinhart, Hillary ; Surette, Michael ; Turner, Dan ; Walters, Thomas ; Vallance, Bruce ; Aumais, Guy ; Bitton, Alain ; Cino, Maria ; Critch, Jeff ; Denson, Lee ; Deslandres, Colette ; El-Matary, Wael ; Herfarth, Hans ; Higgins, Peter ; Huynh, Hien ; Hyams, Jeff ; Mack, David ; McGrath, Jerry ; Otley, Anthony ; Panancionne, Remo ; Baldassano, Robert ; Griffiths, Anne M. ; Hedin, Charlotte ; Hussey, Seamus ; Hyams, Hien ; Keljo, David ; Kevans, David ; Lees, Charlie ; Murthy, Sanjay ; Panaccione, Remo ; Parekh, Nimisha ; Plamondon, Sophie ; Radford-Smith, Graham ; Rosh, Joel ; Rubin, David ; Schultz, Michael ; Siegel, Corey ; Turner, Dan ; Croitoru, Kenneth

Gastroenterology (New York, N.Y. 1943), 2020-12, Vol.159 (6), p.2092-2100.e5 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Increased Intestinal Permeability Is Associated With Later Development of Crohn’s Disease
Autor: Turpin, Williams ; Lee, Sun-Ho ; Raygoza Garay, Juan Antonio ; Madsen, Karen L. ; Meddings, Jonathan B. ; Bedrani, Larbi ; Power, Namita ; Espin-Garcia, Osvaldo ; Xu, Wei ; Smith, Michelle I. ; Griffiths, Anne M. ; Moayyedi, Paul ; Turner, Dan ; Seidman, Ernest G. ; Steinhart, A. Hillary ; Marshall, John K. ; Jacobson, Kevan ; Mack, David ; Huynh, Hien ; Bernstein, Charles N. ; Paterson, Andrew D. ; Abreu, Maria ; Beck, Paul ; Bernstein, Charles ; Croitoru, Kenneth ; Dieleman, Leo ; Feagan, Brian ; Griffiths, Anne ; Guttman, David ; Jacobson, Kevan ; Kaplan, Gilaad ; Krause, Denis O. ; Madsen, Karen ; Marshall, John ; Moayyedi, Paul ; Ropeleski, Mark ; Seidman, Ernest ; Silverberg, Mark ; Snapper, Scott ; Stadnyk, Andy ; Steinhart, Hillary ; Surette, Michael ; Turner, Dan ; Walters, Thomas ; Vallance, Bruce ; Aumais, Guy ; Bitton, Alain ; Cino, Maria ; Critch, Jeff ; Denson, Lee ; Deslandres, Colette ; El-Matary, Wael ; Herfarth, Hans ; Higgins, Peter ; Huynh, Hien ; Hyams, Jeff ; Mack, David ; McGrath, Jerry ; Otley, Anthony ; Panancionne, Remo ; Baldassano, Robert ; Griffiths, Anne M. ; Hedin, Charlotte ; Hussey, Seamus ; Hyams, Hien ; Keljo, David ; Kevans, David ; Lees, Charlie ; Murthy, Sanjay ; Panaccione, Remo ; Parekh, Nimisha ; Plamondon, Sophie ; Radford-Smith, Graham ; Rosh, Joel ; Rubin, David ; Schultz, Michael ; Siegel, Corey ; Turner, Dan ; Croitoru, Kenneth
Assuntos: Adolescent ; Adult ; Child ; Crohn Disease - epidemiology ; Crohn Disease - pathology ; Crohn’s Risk ; FDR Study ; Female ; Follow-Up Studies ; Gut Barrier ; Humans ; IBD ; Intestinal Mucosa - pathology ; Lactulose - administration & dosage ; Lactulose - metabolism ; Lactulose - urine ; Male ; Mannitol - administration & dosage ; Mannitol - metabolism ; Mannitol - urine ; Medicin och hälsovetenskap ; Permeability ; Prospective Studies ; Renal Elimination ; Risk Factors ; Young Adult
É parte de: Gastroenterology (New York, N.Y. 1943), 2020-12, Vol.159 (6), p.2092-2100.e5
Descrição: Increased intestinal permeability has been associated with Crohn’s disease (CD), but it is not clear whether it is a cause or result of the disease. We performed a prospective study to determine whether increased intestinal permeability is associated with future development of CD. We assessed the intestinal permeability, measured by the urinary fractional excretion of lactulose-to-mannitol ratio (LMR) at recruitment in 1420 asymptomatic first-degree relatives (6–35 years old) of patients with CD (collected from 2008 through 2015). Participants were then followed up for a diagnosis of CD from 2008 to 2017, with a median follow-up time of 7.8 years. We analyzed data from 50 participants who developed CD after a median of 2.7 years during the study period, along with 1370 individuals who remained asymptomatic until October 2017. We used the Cox proportional hazards model to evaluate time-related risk of CD based on the baseline LMR. An abnormal LMR (>0.03) was associated with a diagnosis of CD during the follow-up period (hazard ratio, 3.03; 95% CI, 1.64–5.63; P = 3.97 × 10–4). This association remained significant even when the test was performed more than 3 years before the diagnosis of CD (hazard ratio, 1.62; 95% CI, 1.051–2.50; P = .029). Increased intestinal permeability is associated with later development of CD; these findings support a model in which altered intestinal barrier function contributes to pathogenesis. Abnormal gut barrier function might serve as a biomarker for risk of CD onset. [Display omitted]
Editor: United States: Elsevier Inc
Idioma: Inglês

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Increased Intestinal Permeability Is Associated With Later Development of Crohn’s Disease

United States: Elsevier Inc

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