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Effects of the histamine H3 receptor antagonist ABT-239 on cognition and nicotine-induced memory enhancement in mice

Kruk, Marta ; Miszkiel, Joanna ; McCreary, Andrew C. ; Przegaliński, Edmund ; Filip, Małgorzata ; Biała, Grażyna

Pharmacological reports, 2012, Vol.64 (6), p.1316-1325 [Periódico revisado por pares]

Cham: Elsevier Urban & Partner Sp. z o.o

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Título:
Effects of the histamine H3 receptor antagonist ABT-239 on cognition and nicotine-induced memory enhancement in mice
Autor: Kruk, Marta ; Miszkiel, Joanna ; McCreary, Andrew C. ; Przegaliński, Edmund ; Filip, Małgorzata ; Biała, Grażyna
Assuntos: Animals ; Behavior, Animal - drug effects ; Benzofurans - pharmacology ; Brain - drug effects ; Brain - metabolism ; cognition ; Cognition - drug effects ; Dose-Response Relationship, Drug ; Drug Inverse Agonism ; Drug Safety and Pharmacovigilance ; Histamine H3 Antagonists - pharmacology ; histamine3 receptor ; Male ; Maze Learning - drug effects ; Memory - drug effects ; Mice ; Models, Animal ; modified elevated plus maze ; Motor Activity - drug effects ; nicotine ; Nicotine - pharmacology ; Nicotinic Agonists - pharmacology ; Nootropic Agents - pharmacology ; Pharmacotherapy ; Pharmacy ; Pyrrolidines - pharmacology ; Reaction Time - drug effects ; Receptors, Histamine H3 - drug effects ; Receptors, Histamine H3 - metabolism ; Time Factors
É parte de: Pharmacological reports, 2012, Vol.64 (6), p.1316-1325
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: The strong correlation between central histaminergic and cholinergic pathways on cognitive processes has been reported extensively. However, the role of histamine H3 receptor mechanisms interacting with nicotinic mechanisms has not previously been extensively investigated. The current study was conducted to determine the interactions of nicotinic and histamine H3 receptor systems with regard to learning and memory function using a modified elevated plus-maze test in mice. In this test, the latency for mice to move from the open arm to the enclosed arm (i.e., transfer latency) was used as an index of memory. We tested whether ABT-239 (4-(2-{2-[(2R)-2-methylpyrrolidinyl]ethyl}-benzofuran-5-yl), an H3 receptor antagonist/inverse agonist, had influence on two different stages of memory, i.e., memory acquisition and consolidation (administered prior to or immediately after the first trial, respectively) and whether ABT-239 influenced nicotine-induced memory enhancement. Our results revealed that the acute administration of nicotine (0.035 and 0.175mg/kg), but not of ABT-239 (0.1–3mg/kg) reduced transfer latency in the acquisition and consolidation phases. In combination studies, concomitant administration of either ABT-239 (1 and 3mg/kg) and nicotine (0.035mg/kg), or ABT-239 (0.1mg/kg) and nicotine (0.0175mg/kg) further increased nicotine-induced improvement in both memory acquisition and consolidation. The present data confirm an important role for H3 receptors in regulating nicotine-induced mnemonic effects since inhibition of H3 receptors augmented nicotine-induced memory enhancement in mice.
Editor: Cham: Elsevier Urban & Partner Sp. z o.o
Idioma: Inglês

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Effects of the histamine H3 receptor antagonist ABT-239 on cognition and nicotine-induced memory enhancement in mice

Kruk, Marta ; Miszkiel, Joanna ; McCreary, Andrew C. ; Przegaliński, Edmund ; Filip, Małgorzata ; Biała, Grażyna

Cham: Elsevier Urban & Partner Sp. z o.o

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