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Case Fatality Rate of Cancer Patients with COVID-19 in a New York Hospital System

Mehta, Vikas ; Goel, Sanjay ; Kabarriti, Rafi ; Cole, Daniel ; Goldfinger, Mendel ; Acuna-Villaorduna, Ana ; Pradhan, Kith ; Thota, Raja ; Reissman, Stan ; Sparano, Joseph A ; Gartrell, Benjamin A ; Smith, Richard V ; Ohri, Nitin ; Garg, Madhur ; Racine, Andrew D ; Kalnicki, Shalom ; Perez-Soler, Roman ; Halmos, Balazs ; Verma, Amit

Cancer discovery, 2020-07, Vol.10 (7), p.935-941

United States: American Association for Cancer Research

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Título:
Case Fatality Rate of Cancer Patients with COVID-19 in a New York Hospital System
Autor: Mehta, Vikas ; Goel, Sanjay ; Kabarriti, Rafi ; Cole, Daniel ; Goldfinger, Mendel ; Acuna-Villaorduna, Ana ; Pradhan, Kith ; Thota, Raja ; Reissman, Stan ; Sparano, Joseph A ; Gartrell, Benjamin A ; Smith, Richard V ; Ohri, Nitin ; Garg, Madhur ; Racine, Andrew D ; Kalnicki, Shalom ; Perez-Soler, Roman ; Halmos, Balazs ; Verma, Amit
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; Child ; Child, Preschool ; Coronavirus Infections - complications ; COVID-19 ; Female ; Hospitals, Urban ; Humans ; Infant ; Male ; Middle Aged ; Neoplasms - complications ; Neoplasms - mortality ; New York - epidemiology ; Pandemics ; Pneumonia, Viral - complications ; Research Brief ; SARS-CoV-2 ; Young Adult
É parte de: Cancer discovery, 2020-07, Vol.10 (7), p.935-941
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Patients with cancer are presumed to be at increased risk from COVID-19 infection-related fatality due to underlying malignancy, treatment-related immunosuppression, or increased comorbidities. A total of 218 COVID-19-positive patients from March 18, 2020, to April 8, 2020, with a malignant diagnosis were identified. A total of 61 (28%) patients with cancer died from COVID-19 with a case fatality rate (CFR) of 37% (20/54) for hematologic malignancies and 25% (41/164) for solid malignancies. Six of 11 (55%) patients with lung cancer died from COVID-19 disease. Increased mortality was significantly associated with older age, multiple comorbidities, need for ICU support, and elevated levels of D-dimer, lactate dehydrogenase, and lactate in multivariate analysis. Age-adjusted CFRs in patients with cancer compared with noncancer patients at our institution and New York City reported a significant increase in case fatality for patients with cancer. These data suggest the need for proactive strategies to reduce likelihood of infection and improve early identification in this vulnerable patient population. SIGNIFICANCE: COVID-19 in patients with cancer is associated with a significantly increased risk of case fatality, suggesting the need for proactive strategies to reduce likelihood of infection and improve early identification in this vulnerable patient population. .
Editor: United States: American Association for Cancer Research
Idioma: Inglês

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Case Fatality Rate of Cancer Patients with COVID-19 in a New York Hospital System

United States: American Association for Cancer Research

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