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The Genome Sequence of Saccharomyces eubayanus and the Domestication of Lager-Brewing Yeasts

Baker, EmilyClare ; Wang, Bing ; Bellora, Nicolas ; Peris, David ; Hulfachor, Amanda Beth ; Koshalek, Justin A ; Adams, Marie ; Libkind, Diego ; Hittinger, Chris Todd

Molecular biology and evolution, 2015-11, Vol.32 (11), p.2818-2831 [Periódico revisado por pares]

United States: Oxford Publishing Limited (England)

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Título:
The Genome Sequence of Saccharomyces eubayanus and the Domestication of Lager-Brewing Yeasts
Autor: Baker, EmilyClare ; Wang, Bing ; Bellora, Nicolas ; Peris, David ; Hulfachor, Amanda Beth ; Koshalek, Justin A ; Adams, Marie ; Libkind, Diego ; Hittinger, Chris Todd
Assuntos: Base Sequence ; BASIC BIOLOGICAL SCIENCES ; Beer - microbiology ; Chromosome Mapping ; domestication ; Evolution, Molecular ; Evolutionary biology ; Fast Track ; Fungi ; genome assembly ; Genome, Fungal ; Genomes ; Genomics ; Genotype & phenotype ; hybridization ; Hybridization, Genetic ; lager brewing ; Molecular Sequence Data ; Nonnative species ; Phylogeny ; Saccharomyces - genetics ; Saccharomyces cerevisiae - genetics ; Saccharomyces eubayanus ; Yeast
É parte de: Molecular biology and evolution, 2015-11, Vol.32 (11), p.2818-2831
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
National Science Foundation (NSF)
USDOE Office of Science (SC), Biological and Environmental Research (BER)
FC02-07ER64494; DEB-1253634
Associate editor: Jianzhi Zhang
Descrição: The dramatic phenotypic changes that occur in organisms during domestication leave indelible imprints on their genomes. Although many domesticated plants and animals have been systematically compared with their wild genetic stocks, the molecular and genomic processes underlying fungal domestication have received less attention. Here, we present a nearly complete genome assembly for the recently described yeast species Saccharomyces eubayanus and compare it to the genomes of multiple domesticated alloploid hybrids of S. eubayanus × S. cerevisiae (S. pastorianus syn. S. carlsbergensis), which are used to brew lager-style beers. We find that the S. eubayanus subgenomes of lager-brewing yeasts have experienced increased rates of evolution since hybridization, and that certain genes involved in metabolism may have been particularly affected. Interestingly, the S. eubayanus subgenome underwent an especially strong shift in selection regimes, consistent with more extensive domestication of the S. cerevisiae parent prior to hybridization. In contrast to recent proposals that lager-brewing yeasts were domesticated following a single hybridization event, the radically different neutral site divergences between the subgenomes of the two major lager yeast lineages strongly favor at least two independent origins for the S. cerevisiae × S. eubayanus hybrids that brew lager beers. Our findings demonstrate how this industrially important hybrid has been domesticated along similar evolutionary trajectories on multiple occasions.
Editor: United States: Oxford Publishing Limited (England)
Idioma: Inglês

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The Genome Sequence of Saccharomyces eubayanus and the Domestication of Lager-Brewing Yeasts

Baker, EmilyClare ; Wang, Bing ; Bellora, Nicolas ; Peris, David ; Hulfachor, Amanda Beth ; Koshalek, Justin A ; Adams, Marie ; Libkind, Diego ; Hittinger, Chris Todd

United States: Oxford Publishing Limited (England)

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