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Cocaine and Cardiotoxicity : A Literature Review

Pergolizzi, Joseph V., Jr ; Magnusson, Peter ; LeQuang, Jo Ann K ; Breve, Frank ; Varrassi, Giustino

NEMA Res Inc, Clin Res, Naples, FL 34108 USA 2021

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  • Título:
    Cocaine and Cardiotoxicity : A Literature Review
  • Autor: Pergolizzi, Joseph V., Jr ; Magnusson, Peter ; LeQuang, Jo Ann K ; Breve, Frank ; Varrassi, Giustino
  • Assuntos: beta-blockers ; Cardiac and Cardiovascular Systems ; cocaine ; cocaine-associated angina ; cocaine-associated heart failure ; Kardiologi ; myocardial infarction
  • Notas: 0000-0001-7906-7782
    Cureus, 2021, 13:4
    ISI:000642583600024
    doi:10.7759/cureus.14594
    http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-442905
  • Descrição: Long-term cocaine use, as well as acute cocaine use, is associated with adverse cardiovascular consequences, including arrhythmias, angina, myocardial infarction, heart failure, and other conditions. Over the long term, cocaine can result in structural changes to the heart such as increased left-ventricular mass and decreased left-ventricular end-diastolic volume. Patients arriving with cocaine-associated cardiovascular complaints may not be forthcoming about their cocaine or polysubstance abuse or may be unresponsive. The role of beta-blockers, a first-line treatment for many forms of heart disease, is controversial in this population. Cocaine is a powerful sympathomimetic agent, and it was thought that beta-blockade would result in unopposed alpha-adrenergic stimulation and adverse consequences. A number of small, singlecenter, retrospective and observational studies suggest that beta-blockers may be safe, effective, and beneficial in this population. Further study is needed to clarify the role of beta-blockers in this population.
  • Editor: NEMA Res Inc, Clin Res, Naples, FL 34108 USA
  • Data de criação/publicação: 2021
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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