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Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study

Harboe, Zitta B ; Thomsen, Reimar W ; Riis, Anders ; Valentiner-Branth, Palle ; Christensen, Jens Jørgen ; Lambertsen, Lotte ; Krogfelt, Karen A ; Konradsen, Helle B ; Benfield, Thomas L Klugman, Keith P.

PLoS medicine, 2009-05, Vol.6 (5), p.e1000081-e1000081 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study
Autor: Harboe, Zitta B ; Thomsen, Reimar W ; Riis, Anders ; Valentiner-Branth, Palle ; Christensen, Jens Jørgen ; Lambertsen, Lotte ; Krogfelt, Karen A ; Konradsen, Helle B ; Benfield, Thomas L
Klugman, Keith P.
Assuntos: Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Cohort Studies ; Denmark - epidemiology ; Female ; Humans ; Infectious Diseases/Bacterial Infections ; Infectious Diseases/Epidemiology and Control of Infectious Diseases ; Infectious Diseases/Infectious Diseases of the Nervous System ; Infectious Diseases/Respiratory Infections ; Logistic Models ; Male ; Microbiology/Immunity to Infections ; Microbiology/Medical Microbiology ; Middle Aged ; Multivariate Analysis ; Pediatrics and Child Health ; Pneumococcal Infections - microbiology ; Pneumococcal Infections - mortality ; Pneumococcal Infections - prevention & control ; Pneumococcal Vaccines - immunology ; Pneumococcal Vaccines - therapeutic use ; Prevalence ; Public Health and Epidemiology ; Public Health and Epidemiology/Global Health ; Public Health and Epidemiology/Immunization ; Public Health and Epidemiology/Infectious Diseases ; Respiratory Medicine/Respiratory Infections ; Respiratory Medicine/Respiratory Pediatrics ; Serotyping ; Streptococcus pneumoniae - classification ; Streptococcus pneumoniae - isolation & purification ; Young Adult
É parte de: PLoS medicine, 2009-05, Vol.6 (5), p.e1000081-e1000081
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ICMJE criteria for authorship read and met: ZBH RWT AR PVB JJC LL KAK HBK TLB. Agree with the manuscript's results and conclusions: ZBH RWT AR PVB JJC LL KAK HBK TLB. Designed the experiments/the study: ZBH RWT PVB TLB. Analyzed the data: ZBH AR TLB. Collected data/did experiments for the study: ZBH LL. Wrote the first draft of the paper: ZBH TLB. Contributed to the writing of the paper: ZBH RWT AR PVB JJC LL KAK HBK TLB.
Descrição: Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD). In a nationwide population-based cohort study of IPD in Denmark during 1977-2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio >or=3, p<0.001). In children younger than 5 y, associations between serotypes and mortality were different than in adults but statistical precision was limited because of low overall childhood-related mortality. Specific pneumococcal serotypes strongly and independently affect IPD associated mortality.
Editor: United States: Public Library of Science
Idioma: Inglês

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Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study

Harboe, Zitta B ; Thomsen, Reimar W ; Riis, Anders ; Valentiner-Branth, Palle ; Christensen, Jens Jørgen ; Lambertsen, Lotte ; Krogfelt, Karen A ; Konradsen, Helle B ; Benfield, Thomas L Klugman, Keith P.

United States: Public Library of Science

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