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A protein trisulfide couples dissimilatory sulfate reduction to energy conservation

Santos, André A. ; Venceslau, Sofia S. ; Grein, Fabian ; Leavitt, William D. ; Dahl, Christiane ; Johnston, David T. ; Pereira, Inês A. C.

Science (American Association for the Advancement of Science), 2015-12, Vol.350 (6267), p.1541-1545 [Periódico revisado por pares]

United States: American Association for the Advancement of Science

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Título:
A protein trisulfide couples dissimilatory sulfate reduction to energy conservation
Autor: Santos, André A. ; Venceslau, Sofia S. ; Grein, Fabian ; Leavitt, William D. ; Dahl, Christiane ; Johnston, David T. ; Pereira, Inês A. C.
Assuntos: Archaeal Proteins - chemistry ; Archaeal Proteins - metabolism ; Archaeoglobus fulgidus - enzymology ; Bacteria ; Biogeochemistry ; Crystallography, X-Ray ; Cysteine ; Cysteine - chemistry ; Cysteine - metabolism ; Energy conservation ; Energy Metabolism ; Enzymes ; In vitro testing ; Microbiology ; Oxidation-Reduction ; Pathways ; Proteins ; Proteins - metabolism ; Reduction ; Sulfates ; Sulfates - metabolism ; Sulfides - chemistry ; Sulfides - metabolism ; Sulfites ; Sulfites - metabolism ; Sulfur ; Sulfur - metabolism
É parte de: Science (American Association for the Advancement of Science), 2015-12, Vol.350 (6267), p.1541-1545
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Microbial sulfate reduction has governed Earth's biogeochemical sulfur cycle for at least 2.5 billion years. However, the enzymatic mechanisms behind this pathway are incompletely understood, particulary for the reduction of sulfite—a key intermediate in the pathway. This critical reaction is performed by DsrAB, a widespread enzyme also involved in other dissimilatory sulfur metabolisms. Using in vitro assays with an archaeal DsrAB, supported with genetic experiments in a bacterial system, we show that the product of sulfite reduction by DsrAB is a protein-based trisulfide, in which a sulfite-derived sulfur is bridging two conserved cysteines of DsrC. Physiological studies also reveal that sulfate reduction rates are determined by cellular levels of DsrC. Dissimilatory sulfate reduction couples the four-electron reduction of the DsrC trisulfide to energy conservation.
Editor: United States: American Association for the Advancement of Science
Idioma: Inglês

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A protein trisulfide couples dissimilatory sulfate reduction to energy conservation

Santos, André A. ; Venceslau, Sofia S. ; Grein, Fabian ; Leavitt, William D. ; Dahl, Christiane ; Johnston, David T. ; Pereira, Inês A. C.

United States: American Association for the Advancement of Science

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