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A pH-Responsive System Based on Fluorescence Enhanced Gold Nanoparticles for Renal Targeting Drug Delivery and Fibrosis Therapy

Lai, Xuandi ; Geng, Xinran ; Tan, Lishan ; Hu, Jianqiang ; Wang, Shubin

International journal of nanomedicine, 2020-01, Vol.15, p.5613-5627 [Periódico revisado por pares]

New Zealand: Dove Medical Press Limited

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Título:
A pH-Responsive System Based on Fluorescence Enhanced Gold Nanoparticles for Renal Targeting Drug Delivery and Fibrosis Therapy
Autor: Lai, Xuandi ; Geng, Xinran ; Tan, Lishan ; Hu, Jianqiang ; Wang, Shubin
Assuntos: Animals ; Cell Line ; Cobalt ; Cobalt - chemistry ; Cobalt - pharmacokinetics ; Disease Models, Animal ; Drug Carriers - administration & dosage ; Drug Carriers - chemistry ; drug delivery ; Drug delivery systems ; Drug Delivery Systems - methods ; Drug Liberation ; Fibrosis ; Fluorescence ; Glutathione - chemistry ; Gold - chemistry ; gold nanoparticles ; Hydrogen-Ion Concentration ; Kidney - drug effects ; Kidney - metabolism ; Kidney - pathology ; Kidney Diseases - drug therapy ; Kidney Diseases - pathology ; Metal Nanoparticles - administration & dosage ; Metal Nanoparticles - chemistry ; Mice, Inbred BALB C ; Mononuclear Phagocyte System - drug effects ; Mononuclear Phagocyte System - metabolism ; Nanoparticles ; Original Research ; ph sensitivity ; Pharmaceutical industry ; Rats ; renal fibrosis ; self-assembly ; Ureteral Obstruction
É parte de: International journal of nanomedicine, 2020-01, Vol.15, p.5613-5627
Descrição: Stimuli-responsive gold nano-assemblies have attracted attention as drug delivery systems in the biomedical field. However, there are challenges achieving targeted delivery and controllable drug release for specific diseases. In this study, a glutathione (GSH)-modified fluorescent gold nanoparticle termed AuLA-GSH was prepared and a Co -induced self-assembly drug delivery platform termed AuLA-GSH-Co was constructed. Both the pH-responsive character and drug loading behavior of AuLA-GSH-Co were studied in vitro. Kidney-targeting capability was investigated in vitro and in vivo. Finally, the anti-fibrosis efficiency of AuLA-GSH-Co in a mouse model of unilateral ureteral obstruction (UUO) was explored. AuLA-GSH-Co was sensitive to pH changes and released Co in acidic conditions, allowing it to have controllable drug release abilities. AuLA-GSH-Co was found to improve cellular uptake of Co ions compared to CoCl in vitro. AuLA-GSH exhibited specific renal targeting and prolonged renal retention time with low non-specific accumulation in vivo. Moreover, the anti-fibrosis efficiency of AuLA-GSH-Co was higher compared to CoCl in a mouse model of unilateral ureteral obstruction (UUO). AuLA-GSH-Co could greatly enhance drug delivery efficiency with renal targeting capability and obviously relieve renal fibrosis, providing a promising strategy for renal fibrosis therapy.
Editor: New Zealand: Dove Medical Press Limited
Idioma: Inglês

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A pH-Responsive System Based on Fluorescence Enhanced Gold Nanoparticles for Renal Targeting Drug Delivery and Fibrosis Therapy

Lai, Xuandi ; Geng, Xinran ; Tan, Lishan ; Hu, Jianqiang ; Wang, Shubin

New Zealand: Dove Medical Press Limited

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