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Microglial reaction and neuronal death in the hippocampus of rat models of epilepsy

Tooyama, Ikuo ; Nishimura, Tsutomu ; Nakagawa, Eiji ; Morita, Hiroyuki ; Uemura, Shuji ; Aimi, Yoshinari ; Yasuhara, Osamu ; Kimura, Hiroshi

Neuropathology, 1999-06, Vol.19 (2), p.203-208 [Periódico revisado por pares]

Melbourne, Australia: Blackwell Science Pty

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  • Título:
    Microglial reaction and neuronal death in the hippocampus of rat models of epilepsy
  • Autor: Tooyama, Ikuo ; Nishimura, Tsutomu ; Nakagawa, Eiji ; Morita, Hiroyuki ; Uemura, Shuji ; Aimi, Yoshinari ; Yasuhara, Osamu ; Kimura, Hiroshi
  • Assuntos: DNA fragmentation ; hippocampus ; kainic acid ; major histocompatibility complex antigen ; microglia ; temporal lobe epilepsy
  • É parte de: Neuropathology, 1999-06, Vol.19 (2), p.203-208
  • Notas: ArticleID:NEUP224
    istex:2D2D35DC1A3EE5EFF7E10C78A7D46D76C5767A3F
    ark:/67375/WNG-TLNQ6NCS-D
  • Descrição: Reaction of microglial cells as well as DNA fragmentation in pyramidal cells was investigated using immunohisto‐chemistry and in situ end‐labeling method (TUNEL) in the hippocampus of rats after rapid kindling or kainic acid treatment. In intact rats, no or very little DNA fragmentation was detected in the hippocampus. Resting microglia distributed evenly throughout the hippocampus. Neither major histocompatibility complex antigens class I (MHC I) nor class II (MHC II) immunoreactivity was seen in the hippocampus. In the rapid‐kindling model, no DNA fragmentation, reactive microglia or MHC antigen‐positive cells were present in the hippocampus. In rats given an intraperitoneal injection of kainic acid (12 mg/kg), reactive microglial cells were seen around pyramidal neurons in the CA1 and CA3 field of the hippocampus as well as in the hilus of the dentate gyrus at 3 h. At that point in time, DNA fragmentation was not detected. DNA fragmentation was clearly observed, mainly in the CA1 region of the hippocampus, from 24 h to 4 weeks after the kainic acid injection. The number of reactive microglia was quickly increased and reached a maximum at 7 days after the injection, and continued until 8 weeks thereafter. During this period, many reactive microglia expressed MHC I and MHC II. The present study indicates that epileptic seizures do not depend on microglial activation and that microglial activation is closely related to the neuronal death process induced by kainic acid.
  • Editor: Melbourne, Australia: Blackwell Science Pty
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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