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Phallusialides A–E, Pyrrole-Derived Alkaloids Discovered from a Marine-Derived Micromonospora sp. Bacterium Using MS-Based Metabolomics Approaches

Zhang, Fan ; Braun, Doug R ; Chanana, Shaurya ; Rajski, Scott R ; Bugni, Tim S

Journal of natural products (Washington, D.C.), 2019-12, Vol.82 (12), p.3432-3439 [Periódico revisado por pares]

United States: American Chemical Society and American Society of Pharmacognosy

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Título:
Phallusialides A–E, Pyrrole-Derived Alkaloids Discovered from a Marine-Derived Micromonospora sp. Bacterium Using MS-Based Metabolomics Approaches
Autor: Zhang, Fan ; Braun, Doug R ; Chanana, Shaurya ; Rajski, Scott R ; Bugni, Tim S
Assuntos: Alkaloids - chemistry ; Alkaloids - isolation & purification ; Alkaloids - pharmacology ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Escherichia coli - drug effects ; Metabolomics ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Microbial Sensitivity Tests ; Micromonospora - metabolism ; Molecular Structure ; Pyrroles - chemistry ; Spectrum Analysis - methods
É parte de: Journal of natural products (Washington, D.C.), 2019-12, Vol.82 (12), p.3432-3439
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Integrating MS-based metabolomics approaches, LC–MS–PCA and molecular networking enabled the targeted isolation of five new pyrrole-derived alkaloids, phallusialides A–E (1–5), from a marine-derived Micromonospora sp. bacterium. The structures of 1–5 were elucidated by analysis of their HRMS, MS/MS, and NMR spectroscopic data. The absolute configuration of phallusialide A (1) was determined on the basis of comparisons of experimental and theoretically calculated ECD spectra. Compounds 1 and 2 exhibited antibacterial activity against methicillin resistant S. aureus (MRSA) and E. coli, with MIC values of 32 and 64 μg/mL, respectively, whereas 3–5 showed no antibacterial activity even at 256 μg/mL, yielding important SAR insights for this class of compounds.
Editor: United States: American Chemical Society and American Society of Pharmacognosy
Idioma: Inglês

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Phallusialides A–E, Pyrrole-Derived Alkaloids Discovered from a Marine-Derived Micromonospora sp. Bacterium Using MS-Based Metabolomics Approaches

Zhang, Fan ; Braun, Doug R ; Chanana, Shaurya ; Rajski, Scott R ; Bugni, Tim S

United States: American Chemical Society and American Society of Pharmacognosy

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