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Concentration of adenine nucleotides in blood of predialysis patients with chronic renal failure

Bułło, B ; Marlewski, M ; Manitius, J ; Smoleński, R T ; Rutkowski, B

Polskie archiwum medycyny wewne̦trznej, 1995-11, Vol.94 (5), p.389 [Periódico revisado por pares]

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Título:
Concentration of adenine nucleotides in blood of predialysis patients with chronic renal failure
Autor: Bułło, B ; Marlewski, M ; Manitius, J ; Smoleński, R T ; Rutkowski, B
Assuntos: Adenosine Diphosphate - blood ; Adenosine Monophosphate - blood ; Adenosine Triphosphate - blood ; Adult ; Aged ; Chromatography, High Pressure Liquid ; Creatinine - blood ; Female ; Humans ; Hypoxanthine - blood ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - therapy ; Male ; Middle Aged ; Renal Dialysis
É parte de: Polskie archiwum medycyny wewne̦trznej, 1995-11, Vol.94 (5), p.389
Descrição: Intraerythrocyte and blood level ATP concentration is increased in CRF. But little is known on the blood concentration of ADP and AMP in CRF. HPLC was applied to evaluate the ATP, ADP, AMP concentration in blood of 25 CRF patients, with serum creatinine from 2.4 mg/dl to 14.4 mg/dl treated conservatively. Controls were healthy people, with normal renal function. In CRF ATP was higher (p < 0.001) and ADP, AMP and hypoxanthine were lower (p < 0.001) then in controls. Also ATP correlated (r = 0.78; p < 0.001) with serum phosphate and (r = 0.40; p < 0.05) with serum creatinine in CRF patients. Adenine nucleotides turnover is increased in CRF and this process is related to severity of the disease.
Editor: Poland
Idioma: Polonês

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