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Discovery Projects - Grant ID: DP240101665

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Discovery Projects - Grant ID: DP240101665
Notas: ands.org.au-institution-0166
http://dx.doi.org/10.13039/501100000923
Descrição: Understanding T cell trafficking and function during antigenic interference. Science generally studies antigenic stimulation in isolation, by measuring immunity towards antigens derived from a single pathogen. However, as mammals can harbour more than one infection at any given time, we established a model of antigenic interference using different antigens derived from two unrelated pathogens, influenza A (IAV) and Semliki Forest virus (SFV). Our data show that prior exposure to either IAV or SFV greatly perturbs T cell dynamics. This proposal will study, at cellular and molecular levels, T cell trafficking, function and clonal distribution during antigenic interference, thus advance fundamental knowledge on T cell immunity during antigenic competition, and provide a new paradigm on how we research T cell immunity. | $792,223 | Discovery Projects
Data de criação/publicação: 2026
Idioma: Inglês

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