Idioma:

Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

Zhou, Runhong ; To, Kelvin Kai-Wang ; Wong, Yik-Chun ; Liu, Li ; Zhou, Biao ; Li, Xin ; Huang, Haode ; Mo, Yufei ; Luk, Tsz-Yat ; Lau, Thomas Tsz-Kan ; Yeung, Pauline ; Chan, Wai-Ming ; Wu, Alan Ka-Lun ; Lung, Kwok-Cheung ; Tsang, Owen Tak-Yin ; Leung, Wai-Shing ; Hung, Ivan Fan-Ngai ; Yuen, Kwok-Yung ; Chen, Zhiwei

Immunity (Cambridge, Mass.), 2020-10, Vol.53 (4), p.864-877.e5 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses
Autor: Zhou, Runhong ; To, Kelvin Kai-Wang ; Wong, Yik-Chun ; Liu, Li ; Zhou, Biao ; Li, Xin ; Huang, Haode ; Mo, Yufei ; Luk, Tsz-Yat ; Lau, Thomas Tsz-Kan ; Yeung, Pauline ; Chan, Wai-Ming ; Wu, Alan Ka-Lun ; Lung, Kwok-Cheung ; Tsang, Owen Tak-Yin ; Leung, Wai-Shing ; Hung, Ivan Fan-Ngai ; Yuen, Kwok-Yung ; Chen, Zhiwei
Assuntos: acute infection ; Adult ; Aged ; Antibodies ; Antibodies, Neutralizing - biosynthesis ; Antibodies, Viral - biosynthesis ; Betacoronavirus - immunology ; Betacoronavirus - pathogenicity ; CD4 antigen ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - pathology ; CD4-Positive T-Lymphocytes - virology ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - pathology ; CD8-Positive T-Lymphocytes - virology ; Convalescence ; convalescent ; Coronavirus Infections - complications ; Coronavirus Infections - diagnosis ; Coronavirus Infections - immunology ; Coronavirus Infections - virology ; Coronaviruses ; COVID-19 ; Cytokines ; dendritic cell ; Dendritic cells ; Dendritic Cells - immunology ; Dendritic Cells - pathology ; Dendritic Cells - virology ; Diabetes ; Diabetes Complications ; Diabetes Mellitus - diagnosis ; Diabetes Mellitus - immunology ; Diabetes Mellitus - virology ; Disease Progression ; Disease transmission ; Dyspnea ; Epidemics ; Female ; Flow cytometry ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - diagnosis ; Hypertension - immunology ; Hypertension - virology ; Hypotheses ; Immune system ; Infections ; Killer Cells, Natural - immunology ; Killer Cells, Natural - pathology ; Killer Cells, Natural - virology ; Lymphocyte Activation ; Lymphocyte Count ; Lymphocytes ; Lymphocytes T ; Lymphopenia ; Male ; Middle Aged ; Monocytes ; Monocytes - immunology ; Monocytes - pathology ; Monocytes - virology ; Natural killer cells ; neutralizing antibody ; nucleocapsid protein ; Nucleocapsids ; Pandemics ; Pathogenesis ; Patients ; Pneumonia ; Pneumonia, Viral - complications ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - immunology ; Pneumonia, Viral - virology ; receptor-binding domain ; SARS-CoV-2 ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Severity of Illness Index ; T cell immune response ; Tumor necrosis factor-TNF ; Vaccine development ; Vaccines ; Viral diseases ; Zoonoses
É parte de: Immunity (Cambridge, Mass.), 2020-10, Vol.53 (4), p.864-877.e5
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Lead Contact
These authors contributed equally
Descrição: The SARS-CoV-2 pandemic has resulted in millions of infections, yet the role of host immune responses in early COVID-19 pathogenesis remains unclear. By investigating 17 acute and 24 convalescent patients, we found that acute SARS-CoV-2 infection resulted in broad immune cell reduction including T, natural killer, monocyte, and dendritic cells (DCs). DCs were significantly reduced with functional impairment, and ratios of conventional DCs to plasmacytoid DCs were increased among acute severe patients. Besides lymphocytopenia, although neutralizing antibodies were rapidly and abundantly generated in patients, there were delayed receptor binding domain (RBD)- and nucleocapsid protein (NP)-specific T cell responses during the first 3 weeks after symptoms onset. Moreover, acute RBD- and NP-specific T cell responses included relatively more CD4 T cells than CD8 T cells. Our findings provided evidence that impaired DCs, together with timely inverted strong antibody but weak CD8 T cell responses, could contribute to acute COVID-19 pathogenesis and have implications for vaccine development. [Display omitted] •Acute SARS-CoV-2 infection results in broad immune cell reduction•Both dendritic cells and T cells are functionally impaired•Neutralizing antibodies are rapidly and abundantly generated•RBD- and NP-specific T cells are delayed at the acute stage COVID-19 is an acute disease caused by SARS-CoV-2 infection. We determine how the immune system responds to SARS-CoV-2 at both acute and convalescent stages. Acute SARS-CoV-2 infection results in broad immune cell reduction and functional impairment. While neutralizing antibodies are rapidly generated, antigen-specific T cells are delayed at the acute stage.
Editor: United States: Elsevier Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 3 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

United States: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.