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Excess Mortality in Kidney and Kidney-Pancreas Transplant Recipients in the COVID-19 Pandemic in Portugal—A Cohort Study

Coimbra, Miguel T. ; Francisco, José A. T. S. ; Freitas, Joana C. ; Carvalho, Renata V. ; Vilela, Sara R. B. ; Ribeiro, Catarina I. C. D. ; Silvano, José L. C. S. L. ; Pedroso, Sofia ; Almeida, Manuela ; Martins, La Salete ; Malheiro, Jorge

Transplant international, 2023-09, Vol.36, p.11655-11655 [Periódico revisado por pares]

Frontiers Media S.A

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  • Título:
    Excess Mortality in Kidney and Kidney-Pancreas Transplant Recipients in the COVID-19 Pandemic in Portugal—A Cohort Study
  • Autor: Coimbra, Miguel T. ; Francisco, José A. T. S. ; Freitas, Joana C. ; Carvalho, Renata V. ; Vilela, Sara R. B. ; Ribeiro, Catarina I. C. D. ; Silvano, José L. C. S. L. ; Pedroso, Sofia ; Almeida, Manuela ; Martins, La Salete ; Malheiro, Jorge
  • Assuntos: COVID-19 ; excess mortality ; Health Archive ; kidney transplant ; mortality ; pancreas allograft
  • É parte de: Transplant international, 2023-09, Vol.36, p.11655-11655
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    ObjectType-Undefined-3
    ORCID: Miguel T. Coimbra, orcid.org/0000-0002-3949-7339; José A. T. S. Francisco, orcid.org/0000-0003-4294-8783; Joana C. Freitas, orcid.org/0000-0001-5343-6797; Renata V. Carvalho, orcid.org/0000-0002-1324-7526; Sara R. B. Vilela, orcid.org/0000-0003-3352-9106; Catarina I. C. D. Ribeiro, orcid.org/0000-0001-6813-0336; José L. C. S. L. Silvano, orcid.org/0000-0002-5266-2300
  • Descrição: The COVID-19 pandemic increased morbidity and mortality worldwide, particularly in the Kidney and Kidney-Pancreas Transplant Recipient (KTR/KPTR) population. Aiming at assessing the absolute and relative excess mortality (EM) in a Portuguese KTR/KPTR cohort, we conducted a retrospective observational study of two KTR/KPTRs cohorts: cohort 1 ( P1 ; n = 2,179) between September/2012 and March/2020; cohort 2 ( P2 ; n = 2067) between March/2020, and August/2022. A correlation between relative and absolute EM and age, sex, time from transplantation and cause of death was explored. A total of 145 and 84 deaths by all causes were observed in P1 and P2 , respectively. The absolute EM in P2 versus P1 was 19.2 deaths (observed/expected mortality ratio 1.30, p = 0.006), and the relative EM was 1.47/1,000 person-months (95% CI 1.11–1.93, p = 0.006). Compared to the same period in the general population, the standardized mortality rate by age in P2 was 3.86 (95% CI 2.40–5.31), with a peak at 9.00 (95% CI 4.84–13.16) in P2 C. The higher EM identified in this population was associated, mainly, with COVID-19 infection, with much higher values during the second seasonal COVID-19 peak when compared to the general population, despite generalized vaccination. These highlight the need for further preventive measures and improved therapies in these patients.
  • Editor: Frontiers Media S.A
  • Idioma: Inglês
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