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Compound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses

Hu, Yunhui ; Sun, Jia ; Wang, Tongxing ; Wang, Hairong ; Zhao, Chunlai ; Wang, Wenjia ; Yan, Kaijing ; Yan, Xijun ; Sun, He

Pharmaceutical Biology, 2021, Vol.59 (1), p.1583-1591

Taylor & Francis

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  • Título:
    Compound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses
  • Autor: Hu, Yunhui ; Sun, Jia ; Wang, Tongxing ; Wang, Hairong ; Zhao, Chunlai ; Wang, Wenjia ; Yan, Kaijing ; Yan, Xijun ; Sun, He
  • Assuntos: Hypobaric hypoxia ; inflammation ; NF-κB ; Nrf2 ; traditional Chinese medicine
  • É parte de: Pharmaceutical Biology, 2021, Vol.59 (1), p.1583-1591
  • Descrição: Previous studies indicate that compound Danshen Dripping Pill (CDDP) improves the adaptation to high-altitude exposure. However, its mechanism of action is not clear. To explore the protective effect of CDDP on hypobaric hypoxia (HH) and its possible mechanism. A meta-analysis of 1051 human volunteers was performed to evaluate the effectiveness of CDDP at high altitudes. Male Sprague-Dawley rats were randomized into 5 groups (n = 6): control at normal pressure, model, CDDP-170 mg/kg, CDDP-340 mg/kg and acetazolamide groups. HH was simulated at an altitude of 5500 m for 24 h. Animal blood was collected for arterial blood-gas analysis and cytokines detection and their organs were harvested for pathological examination. Expression levels of AQP1, NF-κB and Nrf2 were determined by immunohistochemical staining. The meta-analysis data indicated that the ratio between the combined RR of the total effective rate and the 95% CI was 0.23 (0.06, 0.91), the SMD and 95% CI of SO 2 was 0.37 (0.12, 0.62). Pre-treatment of CDDP protected rats from HH-induced pulmonary edoema and heart injury, left-shifted oxygen-dissociation curve and decreased P50 (30.25 ± 3.72 vs. 37.23 ± 4.30). Mechanistically, CDDP alleviated HH-reinforced ROS by improving SOD and GPX1 while inhibiting pro-inflammatory cytokines and NF-κB expression. CDDP also decreased HH-evoked D-dimer, erythrocyte aggregation and blood hemorheology, promoting AQP1 and Nrf2 expression. Pre-treatment with CDDP could prevent HH-induced tissue damage, oxidative stress and inflammatory response. Suppressed NF-κB and up-regulated Nrf2 might play significant roles in the mechanism of CDDP.
  • Editor: Taylor & Francis
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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