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Gene–Environment Interactions for Parkinson's Disease

Reynoso, Alexandra ; Torricelli, Roberta ; Jacobs, Benjamin Meir ; Shi, Jingchunzi ; Aslibekyan, Stella ; Norcliffe‐Kaufmann, Lucy ; Noyce, Alastair J ; Heilbron, Karl

Annals of neurology, 2024-04, Vol.95 (4), p.677-687 [Peer Reviewed Journal]

Hoboken, USA: John Wiley & Sons, Inc

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Title:
Gene–Environment Interactions for Parkinson's Disease
Author: Reynoso, Alexandra ; Torricelli, Roberta ; Jacobs, Benjamin Meir ; Shi, Jingchunzi ; Aslibekyan, Stella ; Norcliffe‐Kaufmann, Lucy ; Noyce, Alastair J ; Heilbron, Karl
Subjects: Aetiology ; Body mass index ; Body size ; Caffeine ; Craniocerebral Trauma - complications ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - complications ; Environmental factors ; Gene-Environment Interaction ; Genetic Predisposition to Disease - genetics ; Genetic Risk Score ; Genotypes ; Glucosylceramidase ; Head ; Head injuries ; Humans ; Liability ; Lifestyles ; Movement disorders ; Neurodegenerative diseases ; Parkinson Disease - etiology ; Parkinson Disease - genetics ; Parkinson's disease ; Pesticides ; Physical activity ; Risk ; Risk Factors ; Statistics ; Susceptibility ; Tobacco
Is Part Of: Annals of neurology, 2024-04, Vol.95 (4), p.677-687
Notes: Alexandra Reynoso and Roberta Torricelli contributed equally to this work. Alastair J. Noyce and Karl Heilbron contributed equally to this work.
ObjectType-Article-1
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Description: Objective Parkinson's disease (PD) is a neurodegenerative disorder with complex etiology. Multiple genetic and environmental factors have been associated with PD, but most PD risk remains unexplained. The aim of this study was to test for statistical interactions between PD‐related genetic and environmental exposures in the 23andMe, Inc. research dataset. Methods Using a validated PD polygenic risk score and common PD‐associated variants in the GBA gene, we explored interactions between genetic susceptibility factors and 7 lifestyle and environmental factors: body mass index (BMI), type 2 diabetes (T2D), tobacco use, caffeine consumption, pesticide exposure, head injury, and physical activity (PA). Results We observed that T2D, as well as higher BMI, caffeine consumption, and tobacco use, were associated with lower odds of PD, whereas head injury, pesticide exposure, GBA carrier status, and PD polygenic risk score were associated with higher odds. No significant association was observed between PA and PD. In interaction analyses, we found statistical evidence for an interaction between polygenic risk of PD and the following environmental/lifestyle factors: T2D (p = 6.502 × 10−8), PA (p = 8.745 × 10−5), BMI (p = 4.314 × 10−4), and tobacco use (p = 2.236 × 10−3). Although BMI and tobacco use were associated with lower odds of PD regardless of the extent of individual genetic liability, the direction of the relationship between odds of PD and T2D, as well as PD and PA, varied depending on polygenic risk score. Interpretation We provide preliminary evidence that associations between some environmental and lifestyle factors and PD may be modified by genotype. ANN NEUROL 2024;95:677–687
Publisher: Hoboken, USA: John Wiley & Sons, Inc
Language: English

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Gene–Environment Interactions for Parkinson's Disease

Reynoso, Alexandra ; Torricelli, Roberta ; Jacobs, Benjamin Meir ; Shi, Jingchunzi ; Aslibekyan, Stella ; Norcliffe‐Kaufmann, Lucy ; Noyce, Alastair J ; Heilbron, Karl

Hoboken, USA: John Wiley & Sons, Inc

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