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Double-blind evaluation of analgesic efficacy of orally administered diclofenac, nefopam, and acetylsalicylic acid (ASA) plus codeine in chronic cancer pain

Minotti, Vincenzo ; Patoia, Lucio ; Roila, Fausto ; Basurto, Carlo ; Tonato, Maurizio ; Pasqualucci, Vittorio ; Maresca, Vincenzo ; Del Favero, Albano

Pain (Amsterdam), 1989-02, Vol.36 (2), p.177-183 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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Título:
Double-blind evaluation of analgesic efficacy of orally administered diclofenac, nefopam, and acetylsalicylic acid (ASA) plus codeine in chronic cancer pain
Autor: Minotti, Vincenzo ; Patoia, Lucio ; Roila, Fausto ; Basurto, Carlo ; Tonato, Maurizio ; Pasqualucci, Vittorio ; Maresca, Vincenzo ; Del Favero, Albano
Assuntos: Acetylsalicylic acid ; Administration, Oral ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analgesics ; Analgesics - therapeutic use ; Aspirin - adverse effects ; Aspirin - therapeutic use ; Biological and medical sciences ; Cancer pain ; Chronic Disease ; Clinical Trials as Topic ; Codeine ; Codeine - adverse effects ; Codeine - therapeutic use ; Diclofenac ; Diclofenac - adverse effects ; Diclofenac - therapeutic use ; Double-Blind Method ; Drug Combinations ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Nefopam ; Nefopam - adverse effects ; Nefopam - therapeutic use ; Neoplasms - drug therapy ; Neuropharmacology ; Pain - drug therapy ; Patient Dropouts ; Pharmacology. Drug treatments
É parte de: Pain (Amsterdam), 1989-02, Vol.36 (2), p.177-183
Descrição: The analgesic efficacy and toxicity of oral diclofenac sodium 50 mg (q.i.d.) vs. nefopam 60 mg (q.i.d.) and a combination of 640 mg ASA and 40 mg codeine (q.i.d.) in cancer patients with moderate to severe chronic pain has been evaluated in a randomized double-blind study. Planned duration of treatment was 10 days. Pain intensity was evaluated by a visual analog scale. The length of patient participation in the trial, the patient's final global evaluation and the incidence of side effects were also evaluated. Ninety-nine patients were enrolled in the study. All treatments produced a statistically significant pain relief ( P < 0.01) without differences among groups but only 26 of 99 patients (26.3%) completed the planned treatment period. Mean time in the study was 4.65 days. Inefficacy and side effects were the main reasons for premature treatment interruption. Patients treated with nefopam had a significantly shorter period in the study than patients treated with the other 2 treatments. Adverse effects were slightly more frequent with the nefopam and ASA + codeine regimens. The 3 therapeutic regimens appear to be similar as to analgesic efficacy, but diclofenac presents the advantage of a slightly better safety profile than nefopam and the ASA + codeine combination.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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Double-blind evaluation of analgesic efficacy of orally administered diclofenac, nefopam, and acetylsalicylic acid (ASA) plus codeine in chronic cancer pain

Minotti, Vincenzo ; Patoia, Lucio ; Roila, Fausto ; Basurto, Carlo ; Tonato, Maurizio ; Pasqualucci, Vittorio ; Maresca, Vincenzo ; Del Favero, Albano

Amsterdam: Elsevier B.V

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