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HIV‐Infected Liver and Kidney Transplant Recipients: 1‐ and 3‐Year Outcomes

Roland, M. E. ; Barin, B. ; Carlson, L. ; Frassetto, L. A. ; Terrault, N. A. ; Hirose, R. ; Freise, C. E. ; Benet, L. Z. ; Ascher, N. L. ; Roberts, J. P. ; Murphy, B. ; Keller, M. J. ; Olthoff, K. M. ; Blumberg, E. A. ; Brayman, K. L. ; Bartlett, S. T. ; Davis, C. E. ; McCune, J. M. ; Bredt, B. M. ; Stablein, D. M. ; Stock, P. G.

American journal of transplantation, 2008-02, Vol.8 (2), p.355-365 [Periódico revisado por pares]

Malden, USA: Blackwell Publishing Inc

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Título:
HIV‐Infected Liver and Kidney Transplant Recipients: 1‐ and 3‐Year Outcomes
Autor: Roland, M. E. ; Barin, B. ; Carlson, L. ; Frassetto, L. A. ; Terrault, N. A. ; Hirose, R. ; Freise, C. E. ; Benet, L. Z. ; Ascher, N. L. ; Roberts, J. P. ; Murphy, B. ; Keller, M. J. ; Olthoff, K. M. ; Blumberg, E. A. ; Brayman, K. L. ; Bartlett, S. T. ; Davis, C. E. ; McCune, J. M. ; Bredt, B. M. ; Stablein, D. M. ; Stock, P. G.
Assuntos: Adult ; Antiretroviral Therapy, Highly Active ; Biological and medical sciences ; Cadaver ; CD4 Lymphocyte Count ; end‐stage liver disease ; end‐stage renal disease ; Female ; Follow-Up Studies ; Graft Rejection - epidemiology ; Hepatitis B virus ; Hepatitis B virus (HBV) ; Hepatitis C virus ; HIV ; HIV Infections - complications ; HIV Infections - drug therapy ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Kidney Transplantation - immunology ; Kidney Transplantation - statistics & numerical data ; Liver Transplantation - immunology ; Liver Transplantation - statistics & numerical data ; Living Donors ; Male ; Medical sciences ; Middle Aged ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Time Factors ; Tissue Donors - statistics & numerical data ; transplantation ; Treatment Outcome ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral hepatitis ; Viral Load
É parte de: American journal of transplantation, 2008-02, Vol.8 (2), p.355-365
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Improvements in human immunodeficiency virus (HIV)‐associated mortality make it difficult to deny transplantation based upon futility. Outcomes in the current management era are unknown. This is a prospective series of liver or kidney transplant recipients with stable HIV disease. Eleven liver and 18 kidney transplant recipients were followed for a median of 3.4 years (IQR [interquartile range] 2.9–4.9). One‐ and 3‐year liver recipients’ survival was 91% and 64%, respectively; kidney recipients’ survival was 94%. One‐ and 3‐year liver graft survival was 82% and 64%, respectively; kidney graft survival was 83%. Kidney patient and graft survival were similar to the general transplant population, while liver survival was similar to the older population, based on 1999–2004 transplants in the national database. CD4+ T‐cell counts and HIV RNA levels were stable; and there were two opportunistic infections (OI). The 1‐ and 3‐year cumulative incidence (95% confidence intervals [CI]) of rejection episodes for kidney recipients was 52% (28–75%) and 70% (48–92%), respectively. Two‐thirds of hepatitis C virus (HCV)‐infected patients, but no patient with hepatitis B virus (HBV) infection, recurred. Good transplant and HIV‐related outcomes among kidney transplant recipients, and reasonable outcomes among liver recipients suggest that transplantation is an option for selected HIV‐infected patients cared for at centers with adequate expertise. Good transplant and HIV‐related outcomes among HIV‐infected kidney recipients, and reasonable outcomes among liver transplant recipients, suggest that transplantation is an option for selected HIV‐infected patients cared for at centers with adequate expertise.
Editor: Malden, USA: Blackwell Publishing Inc
Idioma: Inglês

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HIV‐Infected Liver and Kidney Transplant Recipients: 1‐ and 3‐Year Outcomes

Malden, USA: Blackwell Publishing Inc

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