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Atypical modes of bacterial histidine kinase signaling

Willett, Jonathan W. ; Crosson, Sean

Molecular microbiology, 2017-01, Vol.103 (2), p.197-202 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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  • Título:
    Atypical modes of bacterial histidine kinase signaling
  • Autor: Willett, Jonathan W. ; Crosson, Sean
  • Assuntos: Bacteria ; Bacteria - genetics ; Bacterial Proteins - metabolism ; Evolution, Molecular ; Gene expression ; Histidine Kinase - metabolism ; Kinases ; Phosphorylation ; Response Elements ; Signal Transduction
  • É parte de: Molecular microbiology, 2017-01, Vol.103 (2), p.197-202
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    ObjectType-Article-1
    ObjectType-Feature-2
  • Descrição: Summary The environment of a cell has a profound influence on its physiology, development and evolution. Accordingly, the capacity to sense and respond to physical and chemical signals in the environment is an important feature of cellular biology. In bacteria, environmental sensory perception is often regulated by two‐component signal transduction systems (TCSTs). Canonical TCST entails signal‐induced autophosphorylation of a sensor histidine kinase (HK) followed by phosphoryl transfer to a cognate response regulator (RR) protein, which may affect gene expression at multiple levels. Recent studies provide evidence for systems that do not adhere to this archetypal TCST signaling model. We present selected examples of atypical modes of signal transduction including inactivation of HK activity via homo‐ and hetero oligomerization, and cross‐phosphorylation between HKs. These examples highlight mechanisms bacteria use to integrate environmental signals to control complex adaptive processes. Recent studies have defined atypical modes of bacterial histidine kinase interactions, which enable complex signal integration. We highlight some of these unusual examples and discuss their significance within this MicroReview.
  • Editor: England: Blackwell Publishing Ltd
  • Idioma: Inglês
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