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Effect of citric acid crosslinking cellulose-based hydrogels on osteogenic differentiation

Raucci, M. G. ; Alvarez-Perez, M. A. ; Demitri, C. ; Giugliano, D. ; De Benedictis, V. ; Sannino, A. ; Ambrosio, L.

Journal of biomedical materials research. Part A, 2015-06, Vol.103 (6), p.2045-2056 [Periódico revisado por pares]

United States: Blackwell Publishing Ltd

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Título:
Effect of citric acid crosslinking cellulose-based hydrogels on osteogenic differentiation
Autor: Raucci, M. G. ; Alvarez-Perez, M. A. ; Demitri, C. ; Giugliano, D. ; De Benedictis, V. ; Sannino, A. ; Ambrosio, L.
Assuntos: Alkaline Phosphatase - metabolism ; Biomarkers - metabolism ; Biomedical materials ; Cell Adhesion - drug effects ; Cell Differentiation - drug effects ; Cell Line ; Cell Proliferation - drug effects ; Cell Shape - drug effects ; Cellulose - chemistry ; Cellulose - pharmacology ; Citric acid ; Citric Acid - pharmacology ; Cross-Linking Reagents - pharmacology ; Crosslinking ; Differentiation ; human mesenchymal stem cells ; Humans ; Hydrogels ; Hydrogels - pharmacology ; Hydrophilicity ; Hydrophobic and Hydrophilic Interactions ; Mesenchymal Stromal Cells - cytology ; Mesenchymal Stromal Cells - drug effects ; Mesenchymal Stromal Cells - metabolism ; Microscopy, Atomic Force ; natural polymers ; Osteogenesis - drug effects ; osteogenic differentiation ; Rheological properties ; Rheology ; Roughness ; Spectroscopy, Fourier Transform Infrared ; surface properties ; Transcription, Genetic - drug effects ; Viscosity ; Water - chemistry
É parte de: Journal of biomedical materials research. Part A, 2015-06, Vol.103 (6), p.2045-2056
Notas: MERIT n.RBNE08HM7T from the Ministero dell'Università e della Ricerca
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ArticleID:JBMA35343
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Descrição: Understanding the relationships between material surface properties and cellular responses is essential to designing optimal material surfaces for implantation and tissue engineering. In this study, cellulose hydrogels were crosslinked using a non‐toxic and natural component namely citric acid. The chemical treatment induces COOH functional groups that improve the hydrophilicity, roughness, and materials rheological properties. The physiochemical, morphological, and mechanical analyses were performed to analyze the material surface before and after crosslinking. This approach would help determine if the effect of chemical treatment on cellulose hydrogel improves the hydrophilicity, roughness, and rheological properties of the scaffold. In this study, it was demonstrated that the biological responses of human mesenchymal stem cell with regard to cell adhesion, proliferation, and differentiation were influenced in vitro by changing the surface chemistry and roughness. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 2045–2056, 2015.
Editor: United States: Blackwell Publishing Ltd
Idioma: Inglês

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Effect of citric acid crosslinking cellulose-based hydrogels on osteogenic differentiation

Raucci, M. G. ; Alvarez-Perez, M. A. ; Demitri, C. ; Giugliano, D. ; De Benedictis, V. ; Sannino, A. ; Ambrosio, L.

United States: Blackwell Publishing Ltd

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