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Hematopoietic Cell Transplantation

Bashir, Qaiser ; Shpall, Elizabeth J. ; Champlin, Richard E. Holland, James F ; Hong, Waun Ki ; Bast, Robert C ; Kufe, Donald W ; Weichselbaum, Ralph R ; Piccart‐Gebart, Martine ; Hait, William N ; Wang, Hongyang ; Pollock, Raphael E ; Croce, Carlo M

Holland‐Frei Cancer Medicine, 2017, p.1-13

Hoboken, NJ, USA: John Wiley & Sons, Inc

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  • Título:
    Hematopoietic Cell Transplantation
  • Autor: Bashir, Qaiser ; Shpall, Elizabeth J. ; Champlin, Richard E.
  • Holland, James F ; Hong, Waun Ki ; Bast, Robert C ; Kufe, Donald W ; Weichselbaum, Ralph R ; Piccart‐Gebart, Martine ; Hait, William N ; Wang, Hongyang ; Pollock, Raphael E ; Croce, Carlo M
  • É parte de: Holland‐Frei Cancer Medicine, 2017, p.1-13
  • Descrição: Hematopoietic cell transplantation (HCT) is an essential component of therapy for various malignant and nonmalignant conditions and provides the only curative modality for several high‐risk disorders. While HCT can be associated with significant morbidity, meaningful progress has been made to reduce treatment‐related toxicities and improve patient outcomes following HCT. Together with the development of international donor registries and the feasibility of alternative donor transplants, these advances have broadened the indications of HCT in recent years.
    Hematopoietic cell transplantation is an effective therapy for a variety of hematologic malignancies and selected other cancers, immunodeficiency states, and genetic disorders. Refinement of methods has allowed the application of this technique to older patients as well as the use of human leukocyte antigen mismatched donors and products. While toxic, the majority of these treatments have curative potential for otherwise fatal cancers. The immunotherapeutic activity of allotransplantation provides both therapeutic benefit and lessons for future immune treatments of cancer.
  • Editor: Hoboken, NJ, USA: John Wiley & Sons, Inc
  • Idioma: Inglês
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