Idioma:

Esr1 + cells in the ventromedial hypothalamus control female aggression

Hashikawa, Koichi ; Hashikawa, Yoshiko ; Tremblay, Robin ; Zhang, Jiaxing ; Feng, James E ; Sabol, Alexander ; Piper, Walter T ; Lee, Hyosang ; Rudy, Bernardo ; Lin, Dayu

Nature neuroscience, 2017-11, Vol.20 (11), p.1580-1590 [Periódico revisado por pares]

United States: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Esr1 + cells in the ventromedial hypothalamus control female aggression
Autor: Hashikawa, Koichi ; Hashikawa, Yoshiko ; Tremblay, Robin ; Zhang, Jiaxing ; Feng, James E ; Sabol, Alexander ; Piper, Walter T ; Lee, Hyosang ; Rudy, Bernardo ; Lin, Dayu
Assuntos: Activation ; Aggression ; Aggression - physiology ; Aggression - psychology ; Aggressiveness (Psychology) ; Animals ; Brain research ; Comparative analysis ; Deactivation ; Estrogen Receptor alpha - biosynthesis ; Estrogen receptors ; Estrogens ; Female ; Females ; Gene expression ; Hypothalamus ; Hypothalamus (ventromedial) ; Inactivation ; Male ; Males ; Mating ; Medical examination ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons - metabolism ; Progesterone ; Sex differences ; Sex differences (Psychology) ; Sexual Behavior, Animal - physiology ; Subdivisions ; Ventromedial Hypothalamic Nucleus - cytology ; Ventromedial Hypothalamic Nucleus - metabolism
É parte de: Nature neuroscience, 2017-11, Vol.20 (11), p.1580-1590
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work.
Descrição: As an essential means of resolving conflicts, aggression is expressed by both sexes but often at a higher level in males than in females. Recent studies suggest that cells in the ventrolateral part of the ventromedial hypothalamus (VMHvl) that express estrogen receptor-α (Esr1) and progesterone receptor are essential for male but not female mouse aggression. In contrast, here we show that VMHvl cells are indispensable for female aggression. This population was active when females attacked naturally. Inactivation of these cells reduced female aggression whereas their activation elicited attack. Additionally, we found that female VMHvl contains two anatomically distinguishable subdivisions that showed differential gene expression, projection and activation patterns after mating and fighting. These results support an essential role of the VMHvl in both male and female aggression and reveal the existence of two previously unappreciated subdivisions in the female VMHvl that are involved in distinct social behaviors.
Editor: United States: Nature Publishing Group
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Esr1 + cells in the ventromedial hypothalamus control female aggression

Hashikawa, Koichi ; Hashikawa, Yoshiko ; Tremblay, Robin ; Zhang, Jiaxing ; Feng, James E ; Sabol, Alexander ; Piper, Walter T ; Lee, Hyosang ; Rudy, Bernardo ; Lin, Dayu

United States: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.