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A Novel Algorithm to Quantify Coronary Remodeling Using Inferred Normal Dimensions

Falcão, Breno A A ; Falcão, João Luiz A A ; Morais, Gustavo R ; Silva, Rafael C ; Lopes, Augusto C ; Soares, Paulo R ; Mariani, Jr, José ; Kalil-Filho, Roberto ; Edelman, Elazer R ; Lemos, Pedro A

Arquivos brasileiros de cardiologia, 2015-10, Vol.105 (4), p.390-398 [Periódico revisado por pares]

Brazil: Sociedade Brasileira de Cardiologia

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Título:
A Novel Algorithm to Quantify Coronary Remodeling Using Inferred Normal Dimensions
Autor: Falcão, Breno A A ; Falcão, João Luiz A A ; Morais, Gustavo R ; Silva, Rafael C ; Lopes, Augusto C ; Soares, Paulo R ; Mariani, Jr, José ; Kalil-Filho, Roberto ; Edelman, Elazer R ; Lemos, Pedro A
Assuntos: Aged ; Algorithms ; Analysis of Variance ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - pathology ; Coronary Artery Disease - physiopathology ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - pathology ; Coronary Vessels - physiopathology ; Female ; Humans ; Male ; Middle Aged ; Original ; Plaque, Atherosclerotic - diagnostic imaging ; Plaque, Atherosclerotic - pathology ; Plaque, Atherosclerotic - physiopathology ; Predictive Value of Tests ; Prospective Studies ; Reference Values ; Reproducibility of Results ; Ultrasonography, Interventional ; Vascular Remodeling - physiology
É parte de: Arquivos brasileiros de cardiologia, 2015-10, Vol.105 (4), p.390-398
Descrição: Vascular remodeling, the dynamic dimensional change in face of stress, can assume different directions as well as magnitudes in atherosclerotic disease. Classical measurements rely on reference to segments at a distance, risking inappropriate comparison between dislike vessel portions. to explore a new method for quantifying vessel remodeling, based on the comparison between a given target segment and its inferred normal dimensions. Geometric parameters and plaque composition were determined in 67 patients using three-vessel intravascular ultrasound with virtual histology (IVUS-VH). Coronary vessel remodeling at cross-section (n = 27.639) and lesion (n = 618) levels was assessed using classical metrics and a novel analytic algorithm based on the fractional vessel remodeling index (FVRI), which quantifies the total change in arterial wall dimensions related to the estimated normal dimension of the vessel. A prediction model was built to estimate the normal dimension of the vessel for calculation of FVRI. According to the new algorithm, "Ectatic" remodeling pattern was least common, "Complete compensatory" remodeling was present in approximately half of the instances, and "Negative" and "Incomplete compensatory" remodeling types were detected in the remaining. Compared to a traditional diagnostic scheme, FVRI-based classification seemed to better discriminate plaque composition by IVUS-VH. Quantitative assessment of coronary remodeling using target segment dimensions offers a promising approach to evaluate the vessel response to plaque growth/regression.
Editor: Brazil: Sociedade Brasileira de Cardiologia
Idioma: Inglês

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A Novel Algorithm to Quantify Coronary Remodeling Using Inferred Normal Dimensions

Falcão, Breno A A ; Falcão, João Luiz A A ; Morais, Gustavo R ; Silva, Rafael C ; Lopes, Augusto C ; Soares, Paulo R ; Mariani, Jr, José ; Kalil-Filho, Roberto ; Edelman, Elazer R ; Lemos, Pedro A

Brazil: Sociedade Brasileira de Cardiologia

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