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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Long, Justin M. ; Holtzman, David M.

Cell, 2019-10, Vol.179 (2), p.312-339 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
  • Autor: Long, Justin M. ; Holtzman, David M.
  • É parte de: Cell, 2019-10, Vol.179 (2), p.312-339
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    AUTHOR CONTRIBUTIONS
    Conceptualization: J.M.L., D.M.H.; Writing – Original Draft: J.M.L; Writing – Revising and Editing: J.M.L, D.M.H; Funding acquisition: J.M.L, D.M.H; Supervision – D.M.H.
  • Descrição: Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence of extracellular β-amyloid deposition as neuritic plaques and intracellular accumulation of hyperphosphorylated tau as neurofibrillary tangles remains the primary neuropathologic criteria for AD diagnosis. However, a number of recent fundamental discoveries highlight important pathological roles for other critical cellular and molecular processes. Despite this, no disease-modifying treatment currently exists, and numerous phase 3 clinical trials have failed to demonstrate benefits. Here, we review recent advances in our understanding of AD pathobiology and discuss current treatment strategies, highlighting recent clinical trials and opportunities for developing future disease-modifying therapies. Long & Holtzman provide a comprehensive overview of the molecules, cells, and mechanisms of Alzheimer disease pathobiology and therapeutic strategies, critically discussing failed strategies and offering a path forward.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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