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Early Effect of Supplemented Infant Formulae on Intestinal Biomarkers and Microbiota: A Randomized Clinical Trial

Castanet, Mireille ; Costalos, Christos ; Haiden, Nadja ; Hascoet, Jean-Michel ; Berger, Bernard ; Sprenger, Norbert ; Grathwohl, Dominik ; Brüssow, Harald ; De Groot, Nanda ; Steenhout, Philippe ; Pecquet, Sophie ; Benyacoub, Jalil ; Picaud, Jean-Charles

Nutrients, 2020-05, Vol.12 (5), p.1481 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Early Effect of Supplemented Infant Formulae on Intestinal Biomarkers and Microbiota: A Randomized Clinical Trial
Autor: Castanet, Mireille ; Costalos, Christos ; Haiden, Nadja ; Hascoet, Jean-Michel ; Berger, Bernard ; Sprenger, Norbert ; Grathwohl, Dominik ; Brüssow, Harald ; De Groot, Nanda ; Steenhout, Philippe ; Pecquet, Sophie ; Benyacoub, Jalil ; Picaud, Jean-Charles
Assuntos: Age ; Animals ; Babies ; Baby foods ; Bifidobacterium animalis ; Biomarkers ; Breast Feeding ; Breastfeeding & lactation ; Caregivers ; Clinical trials ; Cow's milk ; Dietary Supplements ; Digestive system ; Digestive tract ; Double-Blind Method ; early gut maturation ; Elastase ; Feces ; Feces - microbiology ; Food and Nutrition ; Gastrointestinal Microbiome - physiology ; Human health and pathology ; Humans ; Immunology ; Infant ; Infant Formula - analysis ; infant microbiota ; Infants ; Inflammation ; Inflammatory bowel disease ; Intestinal microflora ; Intestine ; Lactoferrin ; Leukocyte L1 Antigen Complex ; Levels ; Life Sciences ; Maturation ; Metabolism ; Microbiota ; Milk ; Multiple births ; Multivariate analysis ; Neopterin ; Neutrophils ; Newborn babies ; Nutrients ; Oligosaccharides ; Oligosaccharides - analysis ; Pediatrics ; Prebiotics ; Prebiotics - analysis ; Probiotics ; Probiotics - analysis ; Proteins
É parte de: Nutrients, 2020-05, Vol.12 (5), p.1481
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
content type line 23
PMCID: PMC7284641
Descrição: Post-natal gut maturation in infants interrelates maturation of the morphology, digestive, and immunological functions and gut microbiota development. Here, we explored both microbiota development and markers of gut barrier and maturation in healthy term infants during their early life to assess the interconnection of gut functions during different infant formulae regimes. A total of 203 infants were enrolled in this randomized double-blind controlled trial including a breastfed reference group. Infants were fed starter formulae for the first four weeks of life, supplemented with different combination of nutrients (lactoferrin, probiotics ( subsp. ) and prebiotics (Bovine Milk-derived Oligosaccharides-BMOS)) and subsequently fed the control formula up to eight weeks of life. Stool microbiota profiles and biomarkers of early gut maturation, calprotectin (primary outcome), elastase, α-1 antitrypsin (AAT) and neopterin were measured in feces at one, two, four, and eight weeks. Infants fed formula containing BMOS had lower mean calprotectin levels over the first two to four weeks compared to the other formula groups. Elastase and AAT levels were closer to levels observed in breastfed infants. No differences were observed for neopterin. Global differences between the bacterial communities of all groups were assessed by constrained multivariate analysis with hypothesis testing. The canonical correspondence analysis (CCA) at genus level showed overlap between microbiota profiles at one and four weeks of age in the BMOS supplemented formula group with the breastfed reference, dominated by bifidobacteria. Microbiota profiles of all groups at four weeks were significantly associated with the calprotectin levels at 4 (CCA, = 0.018) and eight weeks of age (CCA, = 0.026). A meaningful correlation was observed between changes in microbiota composition and gut maturation marker calprotectin. The supplementation with BMOS seems to favor gut maturation closer to that of breastfed infants.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Early Effect of Supplemented Infant Formulae on Intestinal Biomarkers and Microbiota: A Randomized Clinical Trial

Castanet, Mireille ; Costalos, Christos ; Haiden, Nadja ; Hascoet, Jean-Michel ; Berger, Bernard ; Sprenger, Norbert ; Grathwohl, Dominik ; Brüssow, Harald ; De Groot, Nanda ; Steenhout, Philippe ; Pecquet, Sophie ; Benyacoub, Jalil ; Picaud, Jean-Charles

Switzerland: MDPI AG

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