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The International Criteria for Behçet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria

Davatchi, F. ; Assaad-Khalil, S. ; Calamia, K.T. ; Crook, J.E. ; Sadeghi-Abdollahi, B. ; Schirmer, M. ; Tzellos, T. ; Zouboulis, C.C. ; Akhlagi, M. ; Al-Dalaan, A. ; Alekberova, Z.S. ; Ali, A.A. ; Altenburg, A. ; Arromdee, E. ; Baltaci, M. ; Bastos, M. ; Benamour, S. ; Ben Ghorbel, I. ; Boyvat, A. ; Carvalho, L. ; Chen, W. ; Ben-Chetrit, E. ; Chams-Davatchi, C. ; Correia, J. A. ; Crespo, J. ; Dias, C. ; Dong, Y. ; Paixão-Duarte, F. ; Elmuntaser, K. ; Elonakov, A.V. ; Graña Gil, J. ; Haghdoost, A.-A. ; Hayani, R.M. ; Houman, H. ; Isayeva, A.R. ; Jamshidi, A.R. ; Kaklamanis, P. ; Kumar, A. ; Kyrgidis, A. ; Madanat, W. ; Nadji, A. ; Namba, K. ; Ohno, S. ; Olivieri, I. ; Vaz Patto, J. ; Pipitone, N. ; de Queiroz, M.V. ; Ramos, F. ; Resende, C. ; Rosa, C.M. ; Salvarani, C. ; Serra, M.J. ; Shahram, F. ; Shams, H. ; Sharquie, K.E. ; Sliti-Khanfir, M. ; Tribolet de Abreu, T. ; Vasconcelos, C. ; Vedes, J. ; Wechsler, B. ; Cheng, Y.K. ; Zhang, Z. ; Ziaei, N.

Journal of the European Academy of Dermatology and Venereology, 2014-03, Vol.28 (3), p.338-347 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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  • Título:
    The International Criteria for Behçet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria
  • Autor: Davatchi, F. ; Assaad-Khalil, S. ; Calamia, K.T. ; Crook, J.E. ; Sadeghi-Abdollahi, B. ; Schirmer, M. ; Tzellos, T. ; Zouboulis, C.C. ; Akhlagi, M. ; Al-Dalaan, A. ; Alekberova, Z.S. ; Ali, A.A. ; Altenburg, A. ; Arromdee, E. ; Baltaci, M. ; Bastos, M. ; Benamour, S. ; Ben Ghorbel, I. ; Boyvat, A. ; Carvalho, L. ; Chen, W. ; Ben-Chetrit, E. ; Chams-Davatchi, C. ; Correia, J. A. ; Crespo, J. ; Dias, C. ; Dong, Y. ; Paixão-Duarte, F. ; Elmuntaser, K. ; Elonakov, A.V. ; Graña Gil, J. ; Haghdoost, A.-A. ; Hayani, R.M. ; Houman, H. ; Isayeva, A.R. ; Jamshidi, A.R. ; Kaklamanis, P. ; Kumar, A. ; Kyrgidis, A. ; Madanat, W. ; Nadji, A. ; Namba, K. ; Ohno, S. ; Olivieri, I. ; Vaz Patto, J. ; Pipitone, N. ; de Queiroz, M.V. ; Ramos, F. ; Resende, C. ; Rosa, C.M. ; Salvarani, C. ; Serra, M.J. ; Shahram, F. ; Shams, H. ; Sharquie, K.E. ; Sliti-Khanfir, M. ; Tribolet de Abreu, T. ; Vasconcelos, C. ; Vedes, J. ; Wechsler, B. ; Cheng, Y.K. ; Zhang, Z. ; Ziaei, N.
  • Assuntos: Behcet Syndrome - diagnosis ; Humans ; International Cooperation ; Prospective Studies ; Sensitivity and Specificity
  • É parte de: Journal of the European Academy of Dermatology and Venereology, 2014-03, Vol.28 (3), p.338-347
  • Notas: ark:/67375/WNG-7RMCV02S-Q
    istex:BF10EC6F19348BC5FE31106450247B2461867E49
    Table A1. Frequency of male gender by country (in training set). Table A2. Frequency of oral aphthosis (OA) by country (in training set). Table A3. Frequency of genital aphthosis (GA) by country (in training set). Table A4. Frequency of skin manifestations (SKI2) by country (in training set). Table A5. Frequency of pseudo folliculitis (PF) by country (in training set). Table A6. Frequency of erythema nodosum (EN) by country (in training set). Table A7. Frequency of skin aphthosis (SA) by country (in training set). Table A8. Frequency of ocular lesions (OL) by country (in training set). Table A9. Frequency of anterior uveitis (AU) by country (in training set). Table A10. Frequency of posterior uveitis (PU) by country (in training set). Table A11. Frequency of retinal vasculitis (RV) by country (in training set). Table A12. Frequency of joint manifestations (JNT) by country (in training set). Table A13. Frequency of arthralgia (ARG) by country (in training set). Table A14. Frequency of arthritis (ARTH) by country (in training set). Table A15. Frequency of ankylosing spondylitis (AS) by country (in training set). Table A16. Frequency of neurological manifestations (NEUR) by country (in training set). Table A17. Frequency of peripheral (PER) by country (in training set). Table A18. Frequency of central (CNS) by country (in training set). Table A19. Frequency of vascular manifestations (VAS) by country (in training set). Table A20. Frequency of arterial thrombosis (ATHR) by country (in training set). Table A21. Frequency of large vein thrombosis (LVT) by country (in training set). Table A22. Frequency of phlebitis (PHL) by country (in training set). Table A23. Frequency of superficial phlebitis (SP) by country (in training set). Table A24. Frequency of gastro-intestinal (GI) by country (in training set). Table A25. Frequency of chronic diarrhea (DIAR) by country (in training set). Table A26. Frequency of proctorrhagia (PRO) by country (in training set). Table A27. Frequency of epididymitis (EPID) by country (in training set). Table A28. Frequency of cardiac manifestations (CARD) by country (in training set). Table A29. Frequency of pleuro-pulmonary (PLPU) by country (in training set). Table A30. Frequency of pathergy testing (PATH?) by country (in training set). Table A31. Frequency of pathergy positive test (PATH) by country (in training set). Table A32. Frequency of B51 testing (B51?) by country (in training set). Table A33. Frequency of B51 positive test (B51) by country (in training set). Table A34. Frequency of asking about family history (FH?) by country (in training set). Table A35. Frequency of positive family history (FH) by country (in training set).
    ArticleID:JDV12107
    Funding sources
    Conflict of interest
    No funding source.
    None declared.
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Objective Behçet's disease (BD) is a chronic, relapsing, inflammatory vascular disease with no pathognomonic test. Low sensitivity of the currently applied International Study Group (ISG) clinical diagnostic criteria led to their reassessment. Methods An International Team for the Revision of the International Criteria for BD (from 27 countries) submitted data from 2556 clinically diagnosed BD patients and 1163 controls with BD‐mimicking diseases or presenting at least one major BD sign. These were randomly divided into training and validation sets. Logistic regression, ‘leave‐one‐country‐out’ cross‐validation and clinical judgement were employed to develop new International Criteria for BD (ICBD) with the training data. Existing and new criteria were tested for their performance in the validation set. Results For the ICBD, ocular lesions, oral aphthosis and genital aphthosis are each assigned 2 points, while skin lesions, central nervous system involvement and vascular manifestations 1 point each. The pathergy test, when used, was assigned 1 point. A patient scoring ≥4 points is classified as having BD. In the training set, 93.9% sensitivity and 92.1% specificity were assessed compared with 81.2% sensitivity and 95.9% specificity for the ISG criteria. In the validation set, ICBD demonstrated an unbiased estimate of sensitivity of 94.8% (95% CI: 93.4–95.9%), considerably higher than that of the ISG criteria (85.0%). Specificity (90.5%, 95% CI: 87.9–92.8%) was lower than that of the ISG‐criteria (96.0%), yet still reasonably high. For countries with at least 90%‐of‐cases and controls having a pathergy test, adding 1 point for pathergy test increased the estimate of sensitivity from 95.5% to 98.5%, while barely reducing specificity from 92.1% to 91.6%. Conclusion The new proposed criteria derived from multinational data exhibits much improved sensitivity over the ISG criteria while maintaining reasonable specificity. It is proposed that the ICBD criteria to be adopted both as a guide for diagnosis and classification of BD.
  • Editor: England: Blackwell Publishing Ltd
  • Idioma: Inglês
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