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Quillaja brasiliensis saponins are less toxic than Quil A and have similar properties when used as an adjuvant for a viral antigen preparation

Silveira, F ; Cibulski, S.P ; Varela, A.P ; Marqués, J.M ; Chabalgoity, A ; de Costa, F ; Yendo, A.C.A ; Gosmann, G ; Roehe, P.M ; Fernández, C ; Ferreira, F

Vaccine, 2011-11, Vol.29 (49), p.9177-9182 [Periódico revisado por pares]

Kidlington: Elsevier Ltd

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Título:
Quillaja brasiliensis saponins are less toxic than Quil A and have similar properties when used as an adjuvant for a viral antigen preparation
Autor: Silveira, F ; Cibulski, S.P ; Varela, A.P ; Marqués, J.M ; Chabalgoity, A ; de Costa, F ; Yendo, A.C.A ; Gosmann, G ; Roehe, P.M ; Fernández, C ; Ferreira, F
Assuntos: Adjuvants, Immunologic - pharmacology ; Adjuvants, Immunologic - toxicity ; Allergy and Immunology ; alum ; Animals ; Antibodies, Neutralizing - blood ; Antibodies, Viral - blood ; antigens ; Antigens, Viral - immunology ; Applied microbiology ; Biological and medical sciences ; blood serum ; BoHV-5 ; Bovine herpesvirus 5 ; CD4-Positive T-Lymphocytes - immunology ; Cercopithecus aethiops ; Cytokines - immunology ; cytotoxicity ; Female ; Fundamental and applied biological sciences. Psychology ; Hemolysis ; Herpesviridae Infections - immunology ; Herpesviridae Infections - prevention & control ; Herpesvirus 5, Bovine - pathogenicity ; Humoral and cell responses ; Immunity, Humoral ; immunization ; immunoglobulin G ; interferon-gamma ; interleukin-2 ; leaves ; Low toxicity ; Mice ; Microbiology ; neutralizing antibodies ; Quillaja ; Quillaja - chemistry ; Quillaja brasiliensis ; Quillaja Saponins ; Saponins ; Saponins - immunology ; Saponins - pharmacology ; Saponins - toxicity ; Spleen - immunology ; splenocytes ; vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vero Cells ; Virus vaccine
É parte de: Vaccine, 2011-11, Vol.29 (49), p.9177-9182
Notas: http://dx.doi.org/10.1016/j.vaccine.2011.09.137
Descrição: Highlights ► Quillaja brasiliensis saponins (QB-90U) are less haemolytic and cytotoxic than Quil A. ► QB-90U significantly strengthens the vaccine humoral response in mice. ► The use of QB-90U as adjuvant induces a cellular immune response in mice. ► QB-90U is an adjuvant as effective as Quil A towards a viral antigen.
Editor: Kidlington: Elsevier Ltd
Idioma: Inglês

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Quillaja brasiliensis saponins are less toxic than Quil A and have similar properties when used as an adjuvant for a viral antigen preparation

Silveira, F ; Cibulski, S.P ; Varela, A.P ; Marqués, J.M ; Chabalgoity, A ; de Costa, F ; Yendo, A.C.A ; Gosmann, G ; Roehe, P.M ; Fernández, C ; Ferreira, F

Kidlington: Elsevier Ltd

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