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Engineering protein-based therapeutics through structural and chemical design

Ebrahimi, Sasha B ; Samanta, Devleena

Nature communications, 2023-04, Vol.14 (1), p.2411-2411, Article 2411 [Periódico revisado por pares]

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Título:
Engineering protein-based therapeutics through structural and chemical design
Autor: Ebrahimi, Sasha B ; Samanta, Devleena
Assuntos: Antibodies ; Antigens ; Cell permeability ; Denaturation ; Drug dosages ; Enzymes ; Immunogenicity ; Insulin ; Medical treatment ; Medicine ; Pharmaceuticals ; Pharmacokinetics ; Product development ; Protein Engineering ; Proteins ; Proteins - chemistry ; Proteins - therapeutic use
É parte de: Nature communications, 2023-04, Vol.14 (1), p.2411-2411, Article 2411
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Protein-based therapeutics have led to new paradigms in disease treatment. Projected to be half of the top ten selling drugs in 2023, proteins have emerged as rivaling and, in some cases, superior alternatives to historically used small molecule-based medicines. This review chronicles both well-established and emerging design strategies that have enabled this paradigm shift by transforming protein-based structures that are often prone to denaturation, degradation, and aggregation in vitro and in vivo into highly effective therapeutics. In particular, we discuss strategies for creating structures with increased affinity and targetability, enhanced in vivo stability and pharmacokinetics, improved cell permeability, and reduced amounts of undesired immunogenicity.
Editor: England: Nature Publishing Group
Idioma: Inglês

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