Effects of a high-intensity pulmonary rehabilitation program on the minute ventilation/carbon dioxide output slope during exercise in a cohort of patients with COPD undergoing lung resection for non-small cell lung cancer

• Autor: Perrotta, Fabio ; Cennamo, Antonio ; Cerqua, Francesco Saverio ; Stefanelli, Francesco ; Bianco, Andrea ; Musella, Salvatore ; Rispoli, Marco ; Salvi, Rosario ; Meoli, Ilemando
• Assuntos: Aged ; Carbon Dioxide - metabolism ; Carcinoma, non-small-cell lung ; Carcinoma, Non-Small-Cell Lung - physiopathology ; Carcinoma, Non-Small-Cell Lung - rehabilitation ; Carcinoma, Non-Small-Cell Lung - surgery ; Exercise Test ; Exercise Therapy - methods ; Female ; Forced Expiratory Volume - physiology ; Humans ; Lung Neoplasms - physiopathology ; Lung Neoplasms - rehabilitation ; Lung Neoplasms - surgery ; Male ; Middle Aged ; Original ; Oxygen Consumption - physiology ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Disease, Chronic Obstructive - rehabilitation ; Reference Values ; RESPIRATORY SYSTEM ; Retrospective Studies ; Risk assessment ; Spirometry ; Time Factors ; Treatment Outcome ; Vital Capacity - physiology
• É parte de: Jornal brasileiro de pneumologia, 2019, Vol.45 (6), p.e20180132-e20180132
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• Descrição: Preoperative functional evaluation is central to optimizing the identification of patients with non-small cell lung cancer (NSCLC) who are candidates for surgery. The minute ventilation/carbon dioxide output (VE/VCO2) slope has proven to be a predictor of surgical complications and mortality. Pulmonary rehabilitation programs (PRPs) could influence short-term outcomes in patients with COPD undergoing lung resection. Our objective was to evaluate the effects of a PRP on the VE/VCO2 slope in a cohort of patients with COPD undergoing lung resection for NSCLC. We retrospectively evaluated 25 consecutive patients with COPD participating in a three-week high-intensity PRP prior to undergoing lung surgery for NSCLC, between December of 2015 and January of 2017. Patients underwent complete functional assessment, including spirometry, DLCO measurement, and cardiopulmonary exercise testing. There were no significant differences between the mean pre- and post-PRP values (% of predicted) for FEV1 (61.5 ± 22.0% vs. 62.0 ± 21.1%) and DLCO (67.2 ± 18.1% vs. 67.5 ± 13.2%). Conversely, there were significant improvements in the mean peak oxygen uptake (from 14.7 ± 2.5 to 18.2 ± 2.7 mL/kg per min; p < 0.001) and VE/VCO2 slope (from 32.0 ± 2.8 to 30.1 ± 4.0; p < 0.01). Our results indicate that a high-intensity PRP can improve ventilatory efficiency in patients with COPD undergoing lung resection for NSCLC. Further comprehensive prospective studies are required to corroborate these preliminary results.
  
• Editor: Brazil: Sociedade Brasileira de Pneumologia e Tisiologia
  
• Idioma: Inglês;Português