Idioma:

Factors associated with paradoxical immune response to antiretroviral therapy in HIV infected patients: a case control study

Casotti, Janaina A S ; Passos, Luciana N ; Oliveira, Fabiano J P ; Cerutti, Jr, Crispim

BMC infectious diseases, 2011-11, Vol.11 (1), p.306-306, Article 306 [Periódico revisado por pares]

England: BioMed Central Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Factors associated with paradoxical immune response to antiretroviral therapy in HIV infected patients: a case control study
Autor: Casotti, Janaina A S ; Passos, Luciana N ; Oliveira, Fabiano J P ; Cerutti, Jr, Crispim
Assuntos: Acquired immune deficiency syndrome ; Adult ; AIDS ; Anti-HIV Agents - administration & dosage ; Antiretroviral drugs ; Antiretroviral Therapy, Highly Active - methods ; Brazil ; Case-Control Studies ; CD4 Lymphocyte Count ; Cohort Studies ; Drug therapy ; Female ; Highly active antiretroviral therapy ; HIV ; HIV (Viruses) ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV Infections - virology ; Human immunodeficiency virus ; Humans ; Immune response ; Male ; Middle Aged ; Patient outcomes ; Risk Factors ; Studies ; Treatment Outcome ; Viral Load
É parte de: BMC infectious diseases, 2011-11, Vol.11 (1), p.306-306, Article 306
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: A paradoxical immunologic response (PIR) to Highly Active Antiretroviral Therapy (HAART), defined as viral suppression without CD4 cell-count improvement, has been reported in the literature as 8 to 42%, around 15% in most instances. The present study aims to determine, in a cohort of HIV infected patients in Brazil, what factors were independently associated with such a discordant response to HAART. A case-control study (1:4) matched by gender was conducted among 934 HIV infected patients on HAART in Brazil. patients with PIR, defined as CD4 < 350 cells/mm(3) (hazard ratio for AIDS or death of at least 8.5) and undetectable HIV viral load on HAART for at least one year. similar to cases, but with CD4 counts ≥ 350 cells/mm(3). Eligibility criteria were applied. Data were collected from medical records using a standardized form. Variables were introduced in a hierarchical logistic regression model if a p-value < 0.1 was determined in a bivariate analysis. Among 934 patients, 39 cases and 160 controls were consecutively selected. Factors associated with PIR in the logistic regression model were: total time in use of HAART (OR 0.981; CI 95%: 0.96-0.99), nadir CD4-count (OR 0.985; CI 95%: 0.97-0.99), and time of undetectable HIV viral load (OR 0.969; CI 95%: 0.94-0.99). PIR seems to be related to a delay in the management of immunodeficient patients, as shown by its negative association with nadir CD4-count. Strategies should be implemented to avoid such a delay and improve the adherence to HAART as a way to implement concordant responses.
Editor: England: BioMed Central Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Factors associated with paradoxical immune response to antiretroviral therapy in HIV infected patients: a case control study

Casotti, Janaina A S ; Passos, Luciana N ; Oliveira, Fabiano J P ; Cerutti, Jr, Crispim

England: BioMed Central Ltd

Buscando em bases de dados remotas. Favor aguardar.