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Gestational diabetes mellitus, pre-pregnancy body mass index, and gestational weight gain as risk factors for increased fat mass in Brazilian newborns

Abreu, Laísa R S ; Shirley, Meghan K ; Castro, Natália P ; Euclydes, Verônica V ; Bergamaschi, Denise P ; Luzia, Liania A ; Cruz, Ana M ; Rondó, Patrícia H C Hill, Briony

PloS one, 2019-08, Vol.14 (8), p.e0221971-e0221971 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Gestational diabetes mellitus, pre-pregnancy body mass index, and gestational weight gain as risk factors for increased fat mass in Brazilian newborns
Autor: Abreu, Laísa R S ; Shirley, Meghan K ; Castro, Natália P ; Euclydes, Verônica V ; Bergamaschi, Denise P ; Luzia, Liania A ; Cruz, Ana M ; Rondó, Patrícia H C
Hill, Briony
Assuntos: Adipose Tissue ; Adult ; Age ; Aged ; Babies ; Biology and Life Sciences ; Birth weight ; Body composition ; Body fat ; Body mass ; Body Mass Index ; Body size ; Brazil - epidemiology ; Childhood obesity ; Complications and side effects ; Confidence intervals ; Demographics ; Diabetes ; Diabetes in pregnancy ; Diabetes mellitus ; Diabetes, Gestational - epidemiology ; Diabetes, Gestational - etiology ; Ethnicity ; Female ; Genetic crosses ; Gestational age ; Gestational diabetes ; Gestational Weight Gain ; Glucose ; Glucose tolerance ; Health aspects ; Health care ; Health risk assessment ; Humans ; Hyperglycemia ; Infant, Newborn ; Infants (Newborn) ; Medical records ; Medicine and Health Sciences ; Metabolism ; Middle Aged ; Neonates ; Newborn babies ; Newborn infants ; Nutrition ; Obesity ; Obesity in children ; Obstetrics ; Offspring ; People and Places ; Physical Sciences ; Plethysmography ; Pregnancy ; Pregnant women ; Progeny ; Public health ; Regression analysis ; Research and Analysis Methods ; Risk analysis ; Risk Assessment ; Risk Factors ; Sex ; Socioeconomic Factors ; Statistical analysis ; Systematic review ; Type 2 diabetes ; Weight ; Womens health ; Young Adult
É parte de: PloS one, 2019-08, Vol.14 (8), p.e0221971-e0221971
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Competing Interests: The authors have declared that no competing interests exist.
Descrição: Gestational diabetes mellitus (GDM) is a common complication of pregnancy. It may predispose offspring to increased fat mass (FM) and the development of obesity, however few data from Latin America exist. To investigate the influence of GDM on newborn FM in mother-newborn pairs recruited from a public maternity care center in São Paulo, Brazil. Data were collected cross-sectionally in 2013-2014 from 72 mothers diagnosed with GDM, and 211 mothers with normal glucose tolerance (NGT). Newborn FM was evaluated by air-displacement plethysmography (PEA POD), and relevant demographic and obstetric data were collected from hospital records. Associations between maternal GDM status and newborn FM were investigated by multiple linear regression analysis, with adjustment for maternal age, pre-pregnancy BMI, gestational weight gain, type of delivery, sex of the child, and gestational age. FM was greater in GDM versus NGT newborns in a bivariable model (Median (IQR), GDM: 0.35 (0.3) kg vs. NGT: 0.27 (0.2) kg, p = 0.02), however GDM status was not a significant predictor of FM with adjustment for other variables. Rather, pre-pregnancy BMI (coefficient (β) 1.46; 95% confidence interval (CI) 0.66, 2.27), gestational weight gain (β 1.32; 95% CI 0.49, 2.15), and male sex (β -17.8; 95% CI -27.2, -8.29) predicted newborn FM. Analyzing GDM and NGT groups separately, pre-pregnancy BMI (β 6.75; 95% CI 2.36, 11.1) and gestational weight gain (β 5.64; 95% CI 1.16, 10.1) predicted FM in the GDM group, while male sex alone predicted FM in the NGT group (β -12.3; 95% CI -18.3, -6.34). Combined model results suggest that in our cohort, pre-pregnancy BMI and gestational weight gain are more important risk factors for increased neonatal FM than GDM. However, group-specific model results suggest that GDM status may contribute to variation in the relationship between maternal/offspring factors and FM. Our use of a binary GDM variable in the combined model may have precluded clearer results on this point. Prospective cohort studies including data on maternal pre-pregnancy BMI, GWG, and glycemic profile are needed to better understand associations among these variables and their relative influence on offspring FM.
Editor: United States: Public Library of Science
Idioma: Inglês

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Gestational diabetes mellitus, pre-pregnancy body mass index, and gestational weight gain as risk factors for increased fat mass in Brazilian newborns

Abreu, Laísa R S ; Shirley, Meghan K ; Castro, Natália P ; Euclydes, Verônica V ; Bergamaschi, Denise P ; Luzia, Liania A ; Cruz, Ana M ; Rondó, Patrícia H C Hill, Briony

United States: Public Library of Science

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