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Haploidentical Transplantation for Leukemia
Kanda, Junya ; Chao, Nelson
J
. ;
Rizzieri
, David A.
Current oncology reports, 2010-09, Vol.12 (5), p.292-301
[Periódico revisado por pares]
New York: Current Science Inc
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Título:
Haploidentical Transplantation for Leukemia
Autor:
Kanda, Junya
;
Chao, Nelson
J
.
;
Rizzieri
, David A.
Assuntos:
Clinical Trials as Topic
;
Graft Survival
;
Hematopoietic Stem Cell Transplantation
;
Histocompatibility
;
HLA Antigens - metabolism
;
Humans
;
Leukemia - therapy
;
Medicine
;
Medicine & Public Health
;
Oncology
;
Transplantation, Homologous
É parte de:
Current oncology reports, 2010-09, Vol.12 (5), p.292-301
Notas:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição:
Hematopoietic stem cell transplantation from human leukocyte antigen (HLA)-haploidentical family members offers a potential cure for patients in need of allogeneic immunotherapy who have no immediate access to an HLA-matched donor. The use of ex vivo T-cell–depleted stem cells combined with immuno-myeloablative conditioning has enabled durable donor engraftment with a low incidence of acute graft-versus-host disease despite the HLA disparity. Moreover, additional transplant techniques involving in vivo T-cell depletion and reduced-intensity conditioning have further minimized the risks. However, a major drawback is delayed immune reconstitution leading to infections and high relapse rates, prompting significant research efforts focused on improving recovery in the post-transplant period. Infusions with donor lymphocytes are common, though newer manipulations with a focus on donor natural killer cells hold great promise, as do other modified donor T-cell infusions. Success of these new procedures will make haploidentical transplants safer and more effective, further broadening its appeal.
Editor:
New York: Current Science Inc
Idioma:
Inglês
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