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Regular clinical follow-up of oral potentially malignant disorders results in improved survival for patients who develop oral cancer

Jäwert, Fredrik ; Nyman, Jennie ; Olsson, Emma ; Adok, Claudia ; Helmersson, Madeleine ; Öhman, Jenny

Oral oncology, 2021-10, Vol.121, p.105469-105469, Article 105469 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Regular clinical follow-up of oral potentially malignant disorders results in improved survival for patients who develop oral cancer
Autor: Jäwert, Fredrik ; Nyman, Jennie ; Olsson, Emma ; Adok, Claudia ; Helmersson, Madeleine ; Öhman, Jenny
Assuntos: classification ; complications ; Dentistry ; Early diagnosis ; Head and Neck Neoplasms - diagnosis ; Humans ; leukoplakia ; metaanalysis ; Mouth Diseases - diagnosis ; Mouth neoplasms ; Mouth Neoplasms - diagnosis ; neck ; Odontologi ; Oncology ; Oral leukoplakia ; Oral Surgery & Medicine ; Precancerous Conditions - diagnosis ; Prognosis ; Retrospective Studies ; Squamous cell carcinoma of head and ; Squamous cell carcinoma of head and neck ; Squamous Cell Carcinoma of Head and Neck - diagnosis ; Survival ; Survival Rate ; transformation
É parte de: Oral oncology, 2021-10, Vol.121, p.105469-105469, Article 105469
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: •OPMD patients with regular follow-up are diagnosed at an early stage if OSCC develops.•OPMD patients with regular follow-up have a high survival rate if OSCC develops.•OPMD patients without follow-up have stage and survival similar to other OSCC patients. To evaluate whether clinical follow-up programs of oral potentially malignant disorders (OPMD) result in earlier detection and improved survival rates if malignant transformation occurs, as compared to OPMD patients without follow-up and other patients with oral squamous cell carcinoma (OSCC). Three OSCC groups were retrospectively studied for disease stage at diagnosis and survival rates (N = 739): Group A, patients with OSCC with regular follow-up of preceding OPMD (N = 94); Group B, patients with OSCC with preceding OPMD but no follow-up (N = 68); Group C, patients with OSCC without previously known OPMD diagnosis (N = 577). The patients with OPMD with follow-up (Group A) was diagnosed at a significantly earlier stage and have significantly higher survival rates compared to Group B (p < 0.001 and p = 0.022, respectively) and Group C (p < 0.001 and p < 0.001, respectively). There was no significant difference between Group B and Group C in terms of survival rate (p = 0.143) or stage at diagnosis (p = 0.475). Patients with OPMD and follow-up (Group A) had a 5-year net survival rate of 90.0% (95%CI 80.3–100.8%), as compared to 68.3% percent (95% CI 54.5–85.7) for Group B and 56.1% (95% CI 51.4–61.3) for Group C. The results of this study indicate that regular follow-up of patients with OPMD results in earlier detection of OSCC (if malignant transformation occurs) and improved survival.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Regular clinical follow-up of oral potentially malignant disorders results in improved survival for patients who develop oral cancer

Jäwert, Fredrik ; Nyman, Jennie ; Olsson, Emma ; Adok, Claudia ; Helmersson, Madeleine ; Öhman, Jenny

England: Elsevier Ltd

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