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Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44

Sitia, Roberto ; Anelli, Tiziana ; Alessio, Massimo ; Bachi, Angela ; Bergamelli, Leda ; Bertoli, Gloria ; Camerini, Serena ; Mezghrani, Alexandre ; Ruffato, Elena ; Simmen, Thomas

The EMBO journal, 2003-10, Vol.22 (19), p.5015-5022 [Peer Reviewed Journal]

Chichester, UK: John Wiley & Sons, Ltd

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Title:
Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44
Author: Sitia, Roberto ; Anelli, Tiziana ; Alessio, Massimo ; Bachi, Angela ; Bergamelli, Leda ; Bertoli, Gloria ; Camerini, Serena ; Mezghrani, Alexandre ; Ruffato, Elena ; Simmen, Thomas
Subjects: Animals ; Carrier Proteins - metabolism ; disulfide bond formation ; Endoplasmic Reticulum - metabolism ; Glycoproteins - metabolism ; Humans ; IgM polymerization ; Membrane Glycoproteins ; Membrane Proteins - metabolism ; Molecular Chaperones ; Oxidoreductases ; protein secretion ; Pyrans - metabolism ; quality control ; redox regulation ; Sulfhydryl Compounds - metabolism
Is Part Of: The EMBO journal, 2003-10, Vol.22 (19), p.5015-5022
Notes: ark:/67375/WNG-K5FJNZ56-C
ArticleID:EMBJ7595401
Supplementary material 1Supplementary material 2Supplementary material 3
istex:6EC0A4F101C7896F1449B50CDD4CCF2D9A850E7A
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Present address: Vollum Institute, OSHU, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Corresponding author e-mail: r.sitia@hsr.it
Description: Formation of disulfide bonds, an essential step for the maturation and exit of secretory proteins from the endoplasmic reticulum (ER), is controlled by specific ER‐resident enzymes. A pivotal element in this process is Ero1α, an oxidoreductin that lacks known ER retention motifs. Here we show that ERp44 mediates Ero1α ER localization through the formation of reversible mixed disulfides. ERp44 also prevents the secretion of an unassembled cargo protein with unpaired cysteines. We conclude that ERp44 is a key element in thiol‐mediated retention. It might also favour the maturation of disulfide‐linked oligomeric proteins and their quality control.
Publisher: Chichester, UK: John Wiley & Sons, Ltd
Language: English

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Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44

Sitia, Roberto ; Anelli, Tiziana ; Alessio, Massimo ; Bachi, Angela ; Bergamelli, Leda ; Bertoli, Gloria ; Camerini, Serena ; Mezghrani, Alexandre ; Ruffato, Elena ; Simmen, Thomas

Chichester, UK: John Wiley & Sons, Ltd

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