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Utilization of [Bmim]BF4-MAE on enhancement of γ-oryzanol extraction from rice bran and its tyrosinase inhibitory activity

Arrahman, Arif; Sigalingging, Efendy; Trinovita, Elsa; Saputri, Fadlina Chany; Mun’im, Abdul

Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18115

Universidade de São Paulo. Faculdade de Ciências Farmacêuticas 2020-12-09

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  • Título:
    Utilization of [Bmim]BF4-MAE on enhancement of γ-oryzanol extraction from rice bran and its tyrosinase inhibitory activity
  • Autor: Arrahman, Arif; Sigalingging, Efendy; Trinovita, Elsa; Saputri, Fadlina Chany; Mun’im, Abdul
  • Assuntos: [Bmim]Bf4. Ionic Liquid; Il-Mae; Γ-Oryzanol; Tyrosinase
  • É parte de: Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18115
  • Descrição: This study investigated the effect of ionic liquid (IL)-microwave assisted extraction (MAE) on γ-oryzanol extraction from rice bran (Oryza sativa L.). The conditions included the concentration of IL, liquid (IL)/ solid (sample) ratio, extraction time, and microwave power. The use of 1-butyl-3-methylimidazolium ([Bmim]BF4) as a selected solvent in IL-MAE method was developed for extraction of γ-oryzanol from rice bran. The Box-Behnken design on four factors with response surface methodology (RSM) was used to optimize the experimental conditions. The optimum conditions for the MAE were a [Bmim]BF4 concentration of 0.7 M, liquid/solid ratio of 15 mL/g, extraction time of 10 minutes, and 30% microwave power with a γ-oryzanol value of 0.41 mg/g. The experimental values agreed with those predicted by the RSM models. A microplate reader method was used to determine the IC50 value in tyrosinase inhibitory activity of the extract. An IC50 value of the extract obtained from IL-MAE was 1240 µg/mL. This study suggests that IL-MAE is suitable for the extraction of γ-oryzanol from rice bran and that under the optimum conditions the extract has low activity as a tyrosinase inhibitor.
  • Títulos relacionados: https://www.revistas.usp.br/bjps/article/view/181625/168585
  • Editor: Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
  • Data de criação/publicação: 2020-12-09
  • Formato: Adobe PDF
  • Idioma: Inglês
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