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Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus

Zheng, Meiling ; Hu, Zhi ; Mei, Xiaole ; Ouyang, Lianlian ; Song, Yang ; Zhou, Wenhui ; Kong, Yi ; Wu, Ruifang ; Rao, Shijia ; Long, Hai ; Shi, Wei ; Jing, Hui ; Lu, Shuang ; Wu, Haijing ; Jia, Sujie ; Lu, Qianjin ; Zhao, Ming

Nature communications, 2022-12, Vol.13 (1), p.7489-7489, Article 7489 [Periódico revisado por pares]

England: Nature Publishing Group

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Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus
Autor: Zheng, Meiling ; Hu, Zhi ; Mei, Xiaole ; Ouyang, Lianlian ; Song, Yang ; Zhou, Wenhui ; Kong, Yi ; Wu, Ruifang ; Rao, Shijia ; Long, Hai ; Shi, Wei ; Jing, Hui ; Lu, Shuang ; Wu, Haijing ; Jia, Sujie ; Lu, Qianjin ; Zhao, Ming
Assuntos: CCL20 protein ; CD8 antigen ; CD8-Positive T-Lymphocytes ; Cell interactions ; Chronic conditions ; Dendritic cells ; Discoid lupus erythematosus ; Fibroblasts ; Gene expression ; Gene sequencing ; Heterogeneity ; Humans ; Immune system ; Lesions ; Lupus ; Lupus Erythematosus, Discoid - genetics ; Lupus Erythematosus, Discoid - metabolism ; Lupus Erythematosus, Systemic - genetics ; Lupus Erythematosus, Systemic - metabolism ; Lymphocytes ; Lymphocytes B ; Lymphocytes T ; Macrophages ; Skin - metabolism ; Systemic lupus erythematosus ; Therapeutic targets
É parte de: Nature communications, 2022-12, Vol.13 (1), p.7489-7489, Article 7489
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE) are both types of lupus, yet the characteristics, and differences between them are not fully understood. Here we show single-cell RNA sequencing data of cutaneous lesions from DLE and SLE patients and skin tissues from healthy controls (HCs). We find significantly higher proportions of T cells, B cells and NK cells in DLE than in SLE. Expanded CCL20 keratinocyte, CXCL1 fibroblast, ISG CD4/CD8 T cell, ISG plasma cell, pDC, and NK subclusters are identified in DLE and SLE compared to HC. In addition, we observe higher cell communication scores between cell types such as fibroblasts and macrophage/dendritic cells in cutaneous lesions of DLE and SLE compared to HC. In summary, we clarify the heterogeneous characteristics in cutaneous lesions between DLE and SLE, and discover some specific cell subtypes and ligand-receptor pairs that indicate possible therapeutic targets of lupus erythematosus.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus

Zheng, Meiling ; Hu, Zhi ; Mei, Xiaole ; Ouyang, Lianlian ; Song, Yang ; Zhou, Wenhui ; Kong, Yi ; Wu, Ruifang ; Rao, Shijia ; Long, Hai ; Shi, Wei ; Jing, Hui ; Lu, Shuang ; Wu, Haijing ; Jia, Sujie ; Lu, Qianjin ; Zhao, Ming

England: Nature Publishing Group

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