Idioma:

Cell-mediated immune response: a clinical review of the therapeutic potential of human papillomavirus vaccination

Meyer, Sonja Izquierdo ; Fuglsang, Katrine ; Blaakaer, Jan

Acta obstetricia et gynecologica Scandinavica, 2014-12, Vol.93 (12), p.1209-1218 [Periódico revisado por pares]

United States: Blackwell Publishing Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Cell-mediated immune response: a clinical review of the therapeutic potential of human papillomavirus vaccination
Autor: Meyer, Sonja Izquierdo ; Fuglsang, Katrine ; Blaakaer, Jan
Assuntos: Adult ; cellular immunity ; Cervical cancer ; cervical intraepithelial neoplasia ; Cervical Intraepithelial Neoplasia - immunology ; Cervical Intraepithelial Neoplasia - prevention & control ; Female ; Follow-Up Studies ; human papillomavirus ; Human papillomavirus 16 - drug effects ; Human papillomavirus 16 - pathogenicity ; Human papillomavirus 18 - drug effects ; Human papillomavirus 18 - pathogenicity ; Humans ; immunity ; Immunity, Cellular - drug effects ; Papillomavirus Vaccines - therapeutic use ; Randomized Controlled Trials as Topic ; Uterine Cervical Neoplasms - immunology ; Uterine Cervical Neoplasms - prevention & control ; vaccination ; Young Adult
É parte de: Acta obstetricia et gynecologica Scandinavica, 2014-12, Vol.93 (12), p.1209-1218
Notas: ark:/67375/WNG-FJJ2QF65-P
istex:1CA9FD0AC06CCF88F11FD2DD2AB00191AC2A3266
ArticleID:AOGS12480
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Objective This clinical review aims to assess the efficacy of human papillomavirus 16/18 (HPV16/18) vaccination on the cell‐mediated immune response in women with existing cervical intraepithelial neoplasia or cervical cancer induced by HPV16 or HPV18. Data sources and study selection A focused and thorough literature search conducted in five different databases found 996 publications. Six relevant articles were chosen for further review. In total, 154 patients (>18 years of age) were enrolled in prospective study trials with 3–15 months of follow up. The vaccine applications were administered two to four times. The vaccines contained different combinations of HPV16 and HPV18 and early proteins, E6 and E7. The primary outcome was the cell‐mediated immune response. Correlation to clinical outcome (histopathology) and human leukocyte antigen genes were secondary endpoints. Results All vaccines triggered a detectable cell‐mediated immune response, some of which were statistically significant. Correlations between immunological response and clinical outcome (histopathology) were not significant, so neoplasms may not be susceptible to vaccine‐generated cytotoxic T cells (CD8+). Conclusions Prophylactic HPV vaccines have been introduced to reduce the incidence of cervical cancer in young women. Women already infected with HPV could benefit from a therapeutic HPV vaccination. Hence, it is important to continue the development of therapeutic HPV vaccines to lower the rate of HPV‐associated malignancies and crucial to evaluate vaccine efficacy clinically. This clinical review represents an attempt to elucidate the theories supporting the development of an HPV vaccine with a therapeutic effect on human papillomavirus‐induced malignancies of the cervix.
Editor: United States: Blackwell Publishing Ltd
Idioma: Inglês;Francês;Alemão

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Cell-mediated immune response: a clinical review of the therapeutic potential of human papillomavirus vaccination

Meyer, Sonja Izquierdo ; Fuglsang, Katrine ; Blaakaer, Jan

United States: Blackwell Publishing Ltd

Buscando em bases de dados remotas. Favor aguardar.